REP8839

Thuốc trị ký sinh trùng, chống nhiễm khuẩn

Thuốc Gốc

Small Molecule

REP8839 is a novel methionyl-tRNA synthetase (MetS) inhibitor being developed by Replidyne (GlaxoSmithKline licensed REP8839 to Replidyne in June of 2003).

Dược Lực Học : REP8839 is a novel methionyl-tRNA synthetase (MetS) inhibitor with potent antibacterial activity against clinical isolates of Staphylococcus aureus, Streptococcus pyogenes, and other clinically important gram-positive bacteria but little activity against gram-negative bacteria.

Cơ Chế Tác Dụng : REP8839 is a novel methionyl-tRNA synthetase (MetS) inhibitor being developed by Replidyne (GlaxoSmithKline licensed REP8839 to Replidyne in June of 2003). REP8839 exerts its antibacterial activity through specific inhibition of MetS, a novel target.

Dược Động Học :

▧ Protein binding :
REP8839 is highly bound to human serum proteins.

Chỉ Định : For the treatment of bacterial infections caused by susceptible microorganisms (Staphylococcus aureus, including methicillin-resistant S. aureus (MRSA), and Streptococcus pyogenes).

Tài Liệu Tham Khảo Thêm

drugbank

http://www.drugbank.ca/drugs/DB05224

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