Tìm theo
Rapacuronium
Thuốc Gốc
Small Molecule
CAS: 156137-99-4
CTHH: C37H61BrN2O4
PTK: 677.795
Rapacuronium was withdrawn in 2001 in many countries due to risk of fatal bronchospasm.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C37H61BrN2O4
Phân tử khối
677.795
Monoisotopic mass
676.381471097
InChI
InChI=1S/C37H61N2O4.BrH/c1-6-20-39(21-12-9-13-22-39)32-24-30-28-15-14-27-23-33(42-26(3)40)31(38-18-10-8-11-19-38)25-37(27,5)29(28)16-17-36(30,4)35(32)43-34(41)7-2;/h6,27-33,35H,1,7-25H2,2-5H3;1H/q+1;/p-1/t27-,28+,29-,30-,31-,32-,33-,35-,36-,37-;/m0./s1
InChI Key
InChIKey=LVQTUXZKLGXYIU-GWSNJHLMSA-M
IUPAC Name
1-[(1S,2S,4S,5S,7S,10R,11S,13S,14R,15S)-5-(acetyloxy)-2,15-dimethyl-4-(piperidin-1-yl)-14-(propanoyloxy)tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-13-yl]-1-(prop-2-en-1-yl)piperidin-1-ium bromide
Traditional IUPAC Name
1-[(1S,2S,4S,5S,7S,10R,11S,13S,14R,15S)-5-(acetyloxy)-2,15-dimethyl-4-(piperidin-1-yl)-14-(propanoyloxy)tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-13-yl]-1-(prop-2-en-1-yl)piperidin-1-ium bromide
SMILES
[Br-].[H][C@@]12C[C@@H]([C@H](OC(=O)CC)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])C[C@H](OC(C)=O)[C@H](C[C@]12C)N1CCCCC1)[N+]1(CC=C)CCCCC1
Độ hòa tan
1.82e-05 g/l
logP
2.32
logS
-7.6
pKa (Strongest Basic)
9.65
PSA
55.84 Å2
Refractivity
183.1 m3·mol-1
Polarizability
72.29 Å3
Rotatable Bond Count
9
H Bond Acceptor Count
3
H Bond Donor Count
0
Physiological Charge
2
Number of Rings
6
Bioavailability
1
MDDR-Like Rule
true
Dược Lực Học : Rapacuronium is a rapidly acting, non-depolarizing neuromuscular blocker.
Dược Động Học :

▧ Protein binding :
Variable. Plasma protein binding of rapacuronium was studied in vitro for human plasma by equilibrium dialysis. The protein binding was variable and ranged between 50% and 88%, which was at least partly due to hydrolysis of rapacuronium bromide to its 3-hydroxy metabolite. The specific plasma protein to which rapacuronium binds is unknown. Plasma protein binding of the 3-hydroxy metabolite was not determined.
▧ Metabolism :
Hydrolyzed to active metabolites (Cytochrome P450 system is not involved).
▧ Half Life :
141 minutes (mean)
Chỉ Định : Used in anaesthesia, to aid and enable endotracheal intubation.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Raplon
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB04834
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5311398
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506932
ChemSpider
http://www.chemspider.com/Chemical-Structure.4470889.html
PharmGKB
http://www.pharmgkb.org/drug/PA451227
Wikipedia
http://en.wikipedia.org/wiki/Rapacuronium
RxList
http://www.rxlist.com/cgi/generic/raplon.htm
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