Tìm theo
Ranibizumab
Các tên gọi khác (1) :
  • rhuFab V2
ophthalmics
Thuốc Gốc
Biotech
CAS: 347396-82-1
ATC: S01LA04
ĐG : Genentech Inc. , http://www.gene.com
CTHH: C2158H3282N562O681S12
PTK: 48349.6110
Ranibizumab is a recombinant humanized IgG1 kappa isotype monoclonal antibody fragment designed for intraocular use. Ranibizumab binds to and inhibits the biologic activity of human vascular endothelial growth factor A (VEGF-A). Ranibizumab has a molecular weight of approximately 48 kilodaltons and is produced by an E. coli expression system in a nutrient medium containing the antibiotic tetracycline (tetracycline is not detectable in the final product). Ranibizumab is marketed under the name Lucentis®. It is indicated for the treatment of macular edema after retinal vein occlusion, age-related macular degeneration (wet), and diabetic macular edema.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C2158H3282N562O681S12
Phân tử khối
48349.6110
Độ tan chảy
Not applicable
Độ sôi
Approximately 100 degrees C
Độ hòa tan
Soluble in water.
Dược Lực Học : Ranibizumab is a recombinant humanized IgG1 kappa isotype monoclonal antibody fragment designed for intraocular use. Ranibizumab is a VEGF-A antagonist that binds to and inhibits the biologic activity of active forms of human VEGF-A, including the cleaved form (VEGF110). VEGF-A has been shown to cause neovascularization (angiogenesis) and an increase in vascular permeability, which is thought to contribute to the progression of the neovascular form of age-related macular degeneration (AMD).
Cơ Chế Tác Dụng : Ranibizumab is a recombinant humanized IgG1 kappa isotype monoclonal antibody fragment designed for intraocular use. Ranibizumab binds to and inhibits the biologic activity of human vascular endothelial growth factor A (VEGF-A). Ranibizumab has a molecular weight of approximately 48 kilodaltons and is produced by an E. coli expression system in a nutrient medium containing the antibiotic tetracycline (tetracycline is not detectable in the final product). Ranibizumab is marketed under the name Lucentis®. It is indicated for the treatment of macular edema after retinal vein occlusion, age-related macular degeneration (wet), and diabetic macular edema. Ranibizumab binds to the receptor binding site of active forms of VEGF-A, including the biologically active, cleaved form of this molecule, VEGF110. The binding of ranibizumab to VEGF-A prevents the interaction of VEGF-A with its receptors (VEGFR1 and VEGFR2) on the surface of endothelial cells, reducing endothelial cell proliferation, vascular leakage, and new blood vessel formation.
Dược Động Học :
▧ Absorption :
After monthly intravitreal injections, maximum serum concentrations are minimal around 0.3 ng/mL to 2.36 ng/mL.
▧ Volume of Distribution :
Volume of distribution is insignificant.
▧ Protein binding :
Plasma protein binding is insignificant.
▧ Metabolism :
Metabolism was not quantified.
▧ Half Life :
Approximately 9 days.
▧ Clearance :
Clearance was not quantified.
Độc Tính : The most common toxic effects to the eye are eye pain, vitreous floaters, increased intraocular pressure, conjunctival hemorrhage, intraocular inflammation, and foreign body sensation. Also arterial thromboembolic events have occurred in patients.
Chỉ Định : For the treatment of patients with macular edema after retinal vein occlusion, age-related macular degeneration (wet), and diabetic macular edema.
Liều Lượng & Cách Dùng : Injection, solution - Intravitreal - 10MG/ML
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : Lucentis 0.5 mg vial
    Giá bán buôn : USD >2340.0
    Đơn vị tính : vial
Nhà Sản Xuất
  • Công ty : GENENTECH
    Sản phẩm biệt dược : Lucentis
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01270
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D05697
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/50242-080-01
PharmGKB
http://www.pharmgkb.org/drug/PA164746012
Wikipedia
http://en.wikipedia.org/wiki/Ranibizumab
RxList
http://www.rxlist.com/cgi/generic/lucentis.htm
Drugs.com
http://www.drugs.com/cdi/ranibizumab.html
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