Tìm theo
R115777
Các tên gọi khác (1) :
  • Tipifarnib
Thuốc điều trị ung thư
Thuốc Gốc
Small Molecule
CAS: 192185-68-5
CTHH: C27H22Cl2N4O
PTK: 489.396
R115777 is a substance that is being studied in the treatment of acute myeloid leukemia (AML) and other types of cancer. It belongs to the family of drugs called farnesyltransferase inhibitors. It is also called tipifarnib and Zarnestra.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C27H22Cl2N4O
Phân tử khối
489.396
Monoisotopic mass
488.11706676
InChI
InChI=1S/C27H22Cl2N4O/c1-32-16-31-15-25(32)27(30,18-6-9-20(28)10-7-18)19-8-11-24-23(13-19)22(14-26(34)33(24)2)17-4-3-5-21(29)12-17/h3-16H,30H2,1-2H3/t27-/m1/s1
InChI Key
InChIKey=PLHJCIYEEKOWNM-HHHXNRCGSA-N
IUPAC Name
6-[(R)-amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-1,2-dihydroquinolin-2-one
Traditional IUPAC Name
tipifarnib
SMILES
CN1C=NC=C1[C@@](N)(C1=CC=C(Cl)C=C1)C1=CC2=C(C=C1)N(C)C(=O)C=C2C1=CC(Cl)=CC=C1
Độ hòa tan
4.78e-04 g/l
logP
4.69
logS
-6
pKa (Strongest Basic)
7.74
PSA
64.15 Å2
Refractivity
148.2 m3·mol-1
Polarizability
50.16 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
3
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
5
Bioavailability
1
Rule of Five
true
Dược Lực Học : R115777, a nonpeptidomimetic farnesyl transferase inhibitor, suppresses the growth of human pancreatic adenocarcinoma cell lines. This growth inhibition is associated with modulation in the phosphorylation levels of signal transducers and activators of transcription 3 (STAT3) and extracellular signal-regulated kinases (ERK).
Cơ Chế Tác Dụng : R115777 is a substance that is being studied in the treatment of acute myeloid leukemia (AML) and other types of cancer. It belongs to the family of drugs called farnesyltransferase inhibitors. It is also called tipifarnib and Zarnestra. The farnesyltransferase inhibitors (FTIs) are a class of experimental cancer drugs that target protein farnesyltransferase with the downstream effect of preventing the proper functioning of the Ras protein, which is commonly abnormally active in cancer. After translation, RAS goes through four steps of modification: isoprenylation, proteolysis, methylation and palmitoylation. Isoprenylation involves the enzyme farnesyltransferase (FTase) transferring a farnesyl group from farnesyl pyrophosphate (FPP) to the pre-RAS protein. Also, a related enzyme geranylgeranyltransferase I (GGTase I) has the ability to transfer a geranylgeranyl group to K and N-RAS. Farnesyl is necessary to attach RAS to the cell membrane. Without attachment to the cell membrane, RAS is not able to transfer signals from membrane receptors (Reuter et al., 2000).
Chỉ Định : Investigated for use/treatment in colorectal cancer, leukemia (myeloid), pancreatic cancer, and solid tumors.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Zarnestra
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB04960
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=159324
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=10253567
ChemSpider
http://www.chemspider.com/Chemical-Structure.140122.html
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