Tìm theo
Pyridoxine
Các tên gọi khác (7 ) :
  • 2-Methyl-3-hydroxy-4,5-dihydroxymethylpyridine
  • 3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine
  • 3-Hydroxy-4,5-dimethylol-alpha-picoline
  • 5-Hydroxy-6-methyl-3,4-pyridinedimethanol
  • Pyridoxine
  • Pyridoxol
  • Vitamin B6
Vitamin
Thuốc Gốc
Small Molecule
CAS: 65-23-6
ĐG : Accucaps Industries Ltd. , http://www.accucaps.com
CTHH: C8H11NO3
PTK: 169.1778
Pyridoxine is the 4-methanol form of vitamin B6 and is converted to pyridoxal 5-phosphate in the body. Pyridoxal 5-phosphate is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and vitamin B6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C8H11NO3
Phân tử khối
169.1778
Monoisotopic mass
169.073893223
InChI
InChI=1S/C8H11NO3/c1-5-8(12)7(4-11)6(3-10)2-9-5/h2,10-12H,3-4H2,1H3
InChI Key
InChIKey=LXNHXLLTXMVWPM-UHFFFAOYSA-N
IUPAC Name
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol
Traditional IUPAC Name
pyridoxine
SMILES
CC1=C(O)C(CO)=C(CO)C=N1
Độ tan chảy
159-162 °C
Độ hòa tan
2.2E+005 mg/L
logP
-0.77
logS
-1
pKa (strongest acidic)
9.4
pKa (Strongest Basic)
5.58
PSA
73.58 Å2
Refractivity
44.11 m3·mol-1
Polarizability
17.11 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
4
H Bond Donor Count
3
Physiological Charge
0
Number of Rings
1
Bioavailability
1
Rule of Five
true
Dược Lực Học : Vitamin B6 (pyridoxine) is a water-soluble vitamin used in the prophylaxis and treatment of vitamin B6 deficiency and peripheral neuropathy in those receiving isoniazid (isonicotinic acid hydrazide, INH). Vitamin B6 has been found to lower systolic and diastolic blood pressure in a small group of subjects with essential hypertension. Hypertension is another risk factor for atherosclerosis and coronary heart disease. Another study showed pyridoxine hydrochloride to inhibit ADP- or epinephrine-induced platelet aggregation and to lower total cholesterol levels and increase HDL-cholesterol levels, again in a small group of subjects. Vitamin B6, in the form of pyridoxal 5'-phosphate, was found to protect vascular endothelial cells in culture from injury by activated platelets. Endothelial injury and dysfunction are critical initiating events in the pathogenesis of atherosclerosis. Human studies have demonstrated that vitamin B6 deficiency affects cellular and humoral responses of the immune system. Vitamin B6 deficiency results in altered lymphocyte differentiation and maturation, reduced delayed-type hypersensitivity (DTH) responses, impaired antibody production, decreased lymphocyte proliferation and decreased interleukin (IL)-2 production, among other immunologic activities.
Cơ Chế Tác Dụng : Pyridoxine is the 4-methanol form of vitamin B6 and is converted to pyridoxal 5-phosphate in the body. Pyridoxal 5-phosphate is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and vitamin B6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading. [PubChem] Vitamin B6 is the collective term for a group of three related compounds, pyridoxine (PN), pyridoxal (PL) and pyridoxamine (PM), and their phosphorylated derivatives, pyridoxine 5'-phosphate (PNP), pyridoxal 5'-phosphate (PLP) and pyridoxamine 5'-phosphate (PMP). Although all six of these compounds should technically be referred to as vitamin B6, the term vitamin B6 is commonly used interchangeably with just one of them, pyridoxine. Vitamin B6, principally in its biologically active coenzyme form pyridoxal 5'-phosphate, is involved in a wide range of biochemical reactions, including the metabolism of amino acids and glycogen, the synthesis of nucleic acids, hemogloblin, sphingomyelin and other sphingolipids, and the synthesis of the neurotransmitters serotonin, dopamine, norepinephrine and gamma-aminobutyric acid (GABA).
Dược Động Học :
▧ Absorption :
The B vitamins are readily absorbed from the gastrointestinal tract, except in malabsorption syndromes. Pyridoxine is absorbed mainly in the jejunum.
▧ Protein binding :
22%
▧ Metabolism :
Hepatic.
▧ Half Life :
15-20 days
Độc Tính : Oral Rat LD50 = 4 gm/kg. Toxic effects include convulsions, dyspnea, hypermotility, diarrhea, ataxia and muscle weakness.
Chỉ Định : For the treatment of vitamin B6 deficiency and for the prophylaxis of isoniazid-induced peripheral neuropathy.
Liều Lượng & Cách Dùng : Liquid - Intramuscular
Solution - Intramuscular
Solution / drops - Oral
Tablet - Oral
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Becilan
  • Công ty :
    Sản phẩm biệt dược : Beesix
  • Công ty :
    Sản phẩm biệt dược : Benadon
  • Công ty :
    Sản phẩm biệt dược : Bonasanit
  • Công ty :
    Sản phẩm biệt dược : Hexa-Betalin
  • Công ty :
    Sản phẩm biệt dược : Hexobion
  • Công ty :
    Sản phẩm biệt dược : Nestrex
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00165
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C00314
PharmGKB
http://www.pharmgkb.org/drug/PA451897
Wikipedia
http://en.wikipedia.org/wiki/Pyridoxine
PDRhealth
http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/vit_0215.shtml
Drugs.com
http://www.drugs.com/cdi/pyridoxine-vitamin-b6-extended-release-tablets.html
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