Tìm theo
Pyridoxal
Các tên gọi khác (3) :
  • 3-HYDROXY-5-(hydroxymethyl)-2-methylisonicotinaldehyde
  • Pyridoxal
  • Pyridoxaldehyde
Vitamin
Thuốc Gốc
Small Molecule
CAS: 65-22-5
ATC: C10AX07
ĐG : Medisca Inc. , http://www.medisca.com
CTHH: C8H9NO3
PTK: 167.162
The 4-carboxyaldehyde form of vitamin B 6 which is converted to pyridoxal phosphate which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C8H9NO3
Phân tử khối
167.162
Monoisotopic mass
167.058243159
InChI
InChI=1S/C8H9NO3/c1-5-8(12)7(4-11)6(3-10)2-9-5/h2,4,10,12H,3H2,1H3
InChI Key
InChIKey=RADKZDMFGJYCBB-UHFFFAOYSA-N
IUPAC Name
3-hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carbaldehyde
Traditional IUPAC Name
pyridoxal
SMILES
CC1=NC=C(CO)C(C=O)=C1O
Độ tan chảy
165 °C
Độ hòa tan
5E+005 mg/L
logS
-1.2
pKa (strongest acidic)
7.97
pKa (Strongest Basic)
4.11
PSA
70.42 Å2
Refractivity
43.87 m3·mol-1
Polarizability
16.28 Å3
logP
0
Rotatable Bond Count
2
H Bond Acceptor Count
4
H Bond Donor Count
2
Physiological Charge
0
Number of Rings
1
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Pyridoxal principally in the form of the coenzyme pyridoxal 5'-phosphate, is involved in a wide range of biochemical reactions, including the metabolism of amino acids and glycogen, the synthesis of nucleic acids, hemogloblin, sphingomyelin and other sphingolipids, and the synthesis of the neurotransmitters serotonin, dopamine, norepinephrine and gamma-aminobutyric acid (GABA).
Cơ Chế Tác Dụng : The 4-carboxyaldehyde form of vitamin B 6 which is converted to pyridoxal phosphate which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. [PubChem] Pyridoxal is the precursor to pyridoxal phosphate. Pyridoxal 5'-phosphate is involved in a wide range of biochemical reactions, including the metabolism of amino acids and glycogen, the synthesis of nucleic acids, hemogloblin, sphingomyelin and other sphingolipids, and the synthesis of the neurotransmitters serotonin, dopamine, norepinephrine and gamma-aminobutyric acid (GABA).
Độc Tính : Oral LD50 Rat: 2150 mg/kg, Oral LD50 Mouse: 1800 mg/kg
Chỉ Định : Pyridoxal is one of the natural forms available of vitamin B6, therefore, it is used for nutritional supplementation and for treating dietary shortage or imbalances.
Dữ Kiện Thương Mại
Giá thị trường
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00147
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=1050
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506282
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C00250
ChemSpider
http://www.chemspider.com/Chemical-Structure.1021.html
PharmGKB
http://www.pharmgkb.org/drug/PA164749166
Wikipedia
http://en.wikipedia.org/wiki/Pyridoxal
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