Tìm theo
Pyridoxal Phosphate
Các tên gọi khác (7 ) :
  • Codecarboxylase
  • PLP
  • Pyridoxal 5-phosphate
  • Pyridoxal 5'-phosphate
  • Pyridoxal P
  • Pyridoxal-5P
  • Pyridoxal-P
Vitamin
Thuốc Gốc
Small Molecule
CAS: 54-47-7
ATC: A11HA02, A11HA06
ĐG : Pamlab LLC , http://www.pamlab.com
CTHH: C8H10NO6P
PTK: 247.1419
This is the active form of vitamin B6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (pyridoxamine). [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C8H10NO6P
Phân tử khối
247.1419
Monoisotopic mass
247.024573569
InChI
InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChI Key
InChIKey=NGVDGCNFYWLIFO-UHFFFAOYSA-N
IUPAC Name
[(4-formyl-5-hydroxy-6-methylpyridin-3-yl)methoxy]phosphonic acid
Traditional IUPAC Name
(4-formyl-5-hydroxy-6-methylpyridin-3-yl)methoxyphosphonic acid
SMILES
CC1=NC=C(COP(O)(O)=O)C(C=O)=C1O
Độ tan chảy
255 °C
Độ hòa tan
Appreciable
logP
-1.2
logS
-1.6
pKa (strongest acidic)
1.68
pKa (Strongest Basic)
4.11
PSA
116.95 Å2
Refractivity
54.75 m3·mol-1
Polarizability
20.9 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
6
H Bond Donor Count
3
Physiological Charge
-2
Number of Rings
1
Bioavailability
1
Rule of Five
true
Dược Lực Học : The two major forms of vitamin B6 are pyridoxine and pyridoxamine. In the liver they are converted to pyridoxal phosphate (PLP) which is a cofactor in many reactions of amino acid metabolism. PLP also is necessary for the enzymatic reaction governing the release of glucose from glycogen. Pyroluria is one potential cause of vitamin B6 deficiency.
Cơ Chế Tác Dụng : This is the active form of vitamin B6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (pyridoxamine). [PubChem] Pyridoxal Phosphate is a coenzyme of many enzymatic reactions. It is the active form of vitamin B6 which comprises three natural organic compounds, pyridoxal, pyridoxamine and pyridoxine. Pyridoxal phosphate acts as a coenzyme in all transamination reactions, and in some decarboxylation and deamination reactions of amino acids. The aldehyde group of pyridoxal phosphate forms a Schiff-base linkage with the epsilon-amino group of a specific lysine group of the aminotransferase enzyme. The alpha-amino group of the amino acid substrate displaces the epsilon-amino group of the active-site lysine residue. The resulting aldimine becomes deprotonated to become a quinoid intermediate, which in turn accepts a proton at a different position to become a ketimine. The resulting ketimine is hydrolysed so that the amino group remains on the protein complex.
Chỉ Định : For nutritional supplementation and for treating dietary shortage or imbalance.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Biosechs
  • Công ty :
    Sản phẩm biệt dược : Himitan
  • Công ty :
    Sản phẩm biệt dược : Vitazechs
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00114
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=1051
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506428
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C00018
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00006
ChemSpider
http://www.chemspider.com/Chemical-Structure.1022.html
PharmGKB
http://www.pharmgkb.org/drug/PA164749650
Wikipedia
http://en.wikipedia.org/wiki/Pyridoxal-phosphate
PDRhealth
http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/vit_0215.shtml
... loading
... loading