Tìm theo
Propylhexedrine
Các tên gọi khác (1) :
  • Dristan inhaler
Thuốc Gốc
Small Molecule
CAS: 3595-11-7
CTHH: C10H21N
PTK: 155.2804
Propylhexedrine is an alpha-adrenergic agonist often used in nasal decongestant inhalers. It is used to give temporary relief for nasal congestion from colds, allergic rhinitis, or allergies.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C10H21N
Phân tử khối
155.2804
Monoisotopic mass
155.167399677
InChI
InChI=1S/C10H21N/c1-9(11-2)8-10-6-4-3-5-7-10/h9-11H,3-8H2,1-2H3
InChI Key
InChIKey=JCRIVQIOJSSCQD-UHFFFAOYSA-N
IUPAC Name
(1-cyclohexylpropan-2-yl)(methyl)amine
Traditional IUPAC Name
propylhexedrine
SMILES
CNC(C)CC1CCCCC1
Độ hòa tan
9.04e-02 g/l
logP
2.7
logS
-3.2
pKa (Strongest Basic)
10.61
PSA
12.03 Å2
Refractivity
49.54 m3·mol-1
Polarizability
20.27 Å3
Rotatable Bond Count
3
H Bond Acceptor Count
1
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
1
Bioavailability
1
Rule of Five
true
Dược Lực Học : Like other monoamine releasing stimulants propylhexedrine is active as a norepinephrine and dopamine releaser in the central nervous system. The acute effects of the drug closely resemble the physiological and psychological effects of an epinephrine-provoked fight-or-flight response, including increased heart rate and blood pressure, vasoconstriction (constriction of the arterial walls), bronchodilation, and hyperglycemia (increased blood sugar).
Cơ Chế Tác Dụng : Propylhexedrine is an alpha-adrenergic agonist often used in nasal decongestant inhalers. It is used to give temporary relief for nasal congestion from colds, allergic rhinitis, or allergies. Propylhexidrine causes the norepinephrine, dopamine, and serotonin (5HT) transporters to reverse their direction of flow. This inversion leads to a release of these transmitters from the vesicles to the cytoplasm and from the cytoplasm to the synapse. It also antagonizes the action of VMAT2, causing the release of more neurotransmitters.
Độc Tính : The signs and symptoms that are produced after the acute overdosage of Propylhexidrine include Psychosis, Burning sensation.
Chỉ Định : It is used to provide temporary symptomatic relief of nasal congestion due to colds, allergies and allergic rhinitis.
Liều Lượng & Cách Dùng : Aerosol - Nasal
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Benzedrex
  • Công ty :
    Sản phẩm biệt dược : Obesin
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB06714
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=7558
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=99443266
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D05637
PharmGKB
http://www.pharmgkb.org/drug/PA165958387
Wikipedia
http://en.wikipedia.org/wiki/Propylhexedrine
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