Tìm theo
Propantheline
Các tên gọi khác (9 ) :
  • Propantelina bromuro
  • Propantelina, bromuro de
  • Propanthelin bromid
  • Propantheline
  • Propanthéline, bromure de
  • Propanthelini Bromidum
  • SID11111683
  • SID11112101
  • SID90340675
anti ulcer agents, muscarinic antagonists, antispasmodics
Thuốc Gốc
Small Molecule
CAS: 298-50-0
ATC: A03AB05
ĐG : Dispensing Solutions , http://www.drxdispensing.com
CTHH: C23H30NO3
PTK: 368.4892
A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C23H30NO3
Phân tử khối
368.4892
Monoisotopic mass
368.222568831
InChI
InChI=1S/C23H30NO3/c1-16(2)24(5,17(3)4)14-15-26-23(25)22-18-10-6-8-12-20(18)27-21-13-9-7-11-19(21)22/h6-13,16-17,22H,14-15H2,1-5H3/q+1
InChI Key
InChIKey=VVWYOYDLCMFIEM-UHFFFAOYSA-N
IUPAC Name
methylbis(propan-2-yl){2-[(9H-xanthen-9-yl)carbonyloxy]ethyl}azanium
Traditional IUPAC Name
propantheline
SMILES
CC(C)[N+](C)(CCOC(=O)C1C2=CC=CC=C2OC2=CC=CC=C12)C(C)C
Độ hòa tan
7.22e-05 g/l
logP
0.36
logS
-6.8
pKa (strongest acidic)
18.1
pKa (Strongest Basic)
-7.2
PSA
35.53 Å2
Refractivity
119.25 m3·mol-1
Polarizability
40.87 Å3
Rotatable Bond Count
7
H Bond Acceptor Count
1
H Bond Donor Count
0
Physiological Charge
1
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
MDDR-Like Rule
true
Dược Lực Học : Propantheline is an anticholinergic drug, a medication that reduces the effect of acetylcholine, a chemical released from nerves that stimulates muscles, by blocking the receptors for acetylcholine on smooth muscle (a type of muscle). It also has a direct relaxing effect on smooth muscle. Propantheline is used to treat or prevent spasm in the muscles of the gastrointestinal tract in the irritable bowel syndrome. In addition, Propantheline inhibits gastrointestinal propulsive motility and decreases gastric acid secretion and controls excessive pharyngeal, tracheal and bronchial secretions.
Cơ Chế Tác Dụng : A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking. [PubChem] Action is achieved via a dual mechanism: (1) a specific anticholinergic effect (antimuscarinic) at the acetylcholine-receptor sites and (2) a direct effect upon smooth muscle (musculotropic).
Dược Động Học :

▧ Route of Elimination :
Approximately 70% of the dose is excreted in the urine, mostly as metabolites.
Chỉ Định : For the treatment of enuresis. It has also been used for hyperhidrosis, and cramps or spasms of the stomach, intestines or bladder.
Tương Tác Thuốc :
  • Donepezil Possible antagonism of action
  • Galantamine Possible antagonism of action
  • Haloperidol The anticholinergic increases the risk of psychosis and tardive dyskinesia
  • Tacrine The therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the anticholinergic, Propantheline, may be reduced due to antagonism. The interaction may be beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both agents.
  • Trimethobenzamide Trimethobenzamide and Propantheline, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
  • Triprolidine Triprolidine and Propantheline, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
  • Trospium Trospium and Propantheline, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Liều Lượng & Cách Dùng : Tablet - Oral
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Medic
    Sản phẩm biệt dược : Ercoril
  • Công ty : Sannova
    Sản phẩm biệt dược : Methaphyllin
  • Công ty : Pfizer
    Sản phẩm biệt dược : Pro Banthine
  • Công ty : Beacon
    Sản phẩm biệt dược : Prokind
  • Công ty : Chin Teng
    Sản phẩm biệt dược : Propanline
  • Công ty : Shou Chan
    Sản phẩm biệt dược : Propantheline
  • Công ty : Sun
    Sản phẩm biệt dược : Spastheline
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00782
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=4934
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507187
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07506
ChemSpider
http://www.chemspider.com/Chemical-Structure.4765.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0054-4721-25
PharmGKB
http://www.pharmgkb.org/drug/PA164746224
Wikipedia
http://en.wikipedia.org/wiki/Propantheline
Drugs.com
http://www.drugs.com/cdi/propantheline.html
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