Tìm theo
Progesterone
Các tên gọi khác (20 ) :
  • (S)-4-Pregnene-3,20-dione
  • (S)-Pregn-4-en-3,20-dione
  • (S)-Progesterone
  • 17alpha-Progesterone
  • 17α-progesterone
  • 4-Pregnene-3,20-dione
  • Agolutin
  • Akrolutin
  • Corpus Luteum Hormone
  • Crinone
  • delta(4)-Pregnene-3,20-dione
  • Gelbkoerperhormon
  • Luteohormone
  • Lutogynon
  • Pregn-4-ene-3,20-dione
  • Progesteron
  • Progesterona
  • Progestérone
  • Progesterone
  • Progesteronum
Hormon, Nội tiết tố
Thuốc Gốc
Small Molecule
CAS: 57-83-0
ATC: G03AC06, G03DA02, G03DA03, G03DA04, L02AB02
ĐG : Abraxis BioScience Inc. , http://www.abraxisbio.com
CTHH: C21H30O2
PTK: 314.4617
The major progestational steroid that is secreted primarily by the corpus luteum and the placenta. Progesterone acts on the uterus, the mammary glands, and the brain. It is required in embryo implantation, pregnancy maintenance, and the development of mammary tissue for milk production. Progesterone, converted from pregnenolone, also serves as an intermediate in the biosynthesis of gonadal steroid hormones and adrenal corticosteroids. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C21H30O2
Phân tử khối
314.4617
Monoisotopic mass
314.224580204
InChI
InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
InChI Key
InChIKey=RJKFOVLPORLFTN-LEKSSAKUSA-N
IUPAC Name
(1S,2R,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one
Traditional IUPAC Name
progesterone
SMILES
[H][C@@]12CC[C@H](C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C
Độ tan chảy
121 °C
Độ hòa tan
8.81 mg/L (at 25 °C)
logP
3.87
logS
-4.43
pKa (strongest acidic)
18.92
pKa (Strongest Basic)
-4.8
PSA
34.14 Å2
Refractivity
92.71 m3·mol-1
Polarizability
37.15 Å3
Rotatable Bond Count
1
H Bond Acceptor Count
2
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
4
Bioavailability
1
Rule of Five
true
Ghose Filter
true
caco2 Permeability
-4.37
Dược Lực Học : Progesterone is a naturally occuring progestin or a synthetic form of the naturally occurring female sex hormone, progesterone. In a woman's normal menstrual cycle, an egg matures and is released from the ovaries (ovulation). The ovary then produces progesterone, preventing the release of further eggs and priming the lining of the womb for a possible pregnancy. If pregnancy occurs, progesterone levels in the body remain high, maintaining the womb lining. If pregnancy does not occur, progesterone levels in the body fall, resulting in a menstrual period. Progesterone tricks the body processes into thinking that ovulation has already occurred by maintaining high levels of the synthetic progesterone. This prevents the release of eggs from the ovaries.
Cơ Chế Tác Dụng : The major progestational steroid that is secreted primarily by the corpus luteum and the placenta. Progesterone acts on the uterus, the mammary glands, and the brain. It is required in embryo implantation, pregnancy maintenance, and the development of mammary tissue for milk production. Progesterone, converted from pregnenolone, also serves as an intermediate in the biosynthesis of gonadal steroid hormones and adrenal corticosteroids. [PubChem] Progesterone shares the pharmacological actions of the progestins. Progesterone binds to the progesterone and estrogen receptors. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins like Progesterone will slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH (luteinizing hormone) surge. In women who have adequate endogenous estrogen, progesterone transforms a proliferative endometrium into a secretory one. Progesterone is essential for the development of decidual tissue and is necessary to increase endometrial receptivity for implantation of an embryo. Once an embryo has been implanted, progesterone acts to maintain the pregnancy. Progesterone also stimulates the growth of mammary alveolar tissue and relaxes uterine smooth muscle. It has little estrogenic and androgenic activity.
Dược Động Học :
▧ Absorption :
Progesterone absorption is prolonged with an absorption half-life of approximately 25-50 hours.
▧ Protein binding :
96%-99%
▧ Metabolism :
Progesterone is metabolized primarily by the liver largely to pregnanediols and pregnanolones.
▧ Route of Elimination :
The glucuronide and sulfate conjugates of pregnanediol and pregnanolone are excreted in the urine and bile. Progesterone metabolites which are excreted in the bile may undergo enterohepatic recycling or may be excreted in the feces. Progesterone metabolites are excreted mainly by the kidneys.
▧ Half Life :
34.8-55.13 hours
▧ Clearance :
* 2510 +/- 135 L/day [cycling women]
Chỉ Định : For progesterone supplementation or replacement as part of an Assisted Reproductive Technology (ART) treatment for infertile women with progesterone deficiency and for the treatment of secondary amenorrhea. Also used for the reduction of the incidence of endometrial hyperplasia and the attendant risk of endometrial carcinoma in postmenopausal women receiving estrogen replacement therapy, as well as treatment of abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology such as fibroids or uterine cancer.
Tương Tác Thuốc :
  • Topotecan The p-glycoprotein inhibitor, Progesterone, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Liều Lượng & Cách Dùng : Capsule - Oral
Gel - Intravaginal
Liquid - Intramuscular
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Biotika
    Sản phẩm biệt dược : Agolutin
  • Công ty : Merck
    Sản phẩm biệt dược : Crinone
  • Công ty : Actavis
    Sản phẩm biệt dược : Cyclogest
  • Công ty : Ferring
    Sản phẩm biệt dược : Endometrin
  • Công ty :
    Sản phẩm biệt dược : Gesterol
  • Công ty : Nordic Pharma
    Sản phẩm biệt dược : Gestone
  • Công ty :
    Sản phẩm biệt dược : Prochieve
  • Công ty :
    Sản phẩm biệt dược : Progestasert
  • Công ty : Besins
    Sản phẩm biệt dược : Progestogel
  • Công ty : Schering-Plough
    Sản phẩm biệt dược : Prometrium
  • Sản phẩm biệt dược : Qi Ning
  • Công ty : Aversi
    Sản phẩm biệt dược : Relantan
  • Công ty : Sun Pharma
    Sản phẩm biệt dược : Susten
  • Công ty : Besins
    Sản phẩm biệt dược : Utrogestan
  • Sản phẩm biệt dược : Utrogestran
  • Công ty : Bestochem
    Sản phẩm biệt dược : Utrovin
  • Công ty : Verisfield
    Sản phẩm biệt dược : Vasclor
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00396
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5994
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508968
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C00410
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00066
ChemSpider
http://www.chemspider.com/Chemical-Structure.5773.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0591-3128-79
PharmGKB
http://www.pharmgkb.org/drug/PA451123
Wikipedia
http://en.wikipedia.org/wiki/Progesterone
RxList
http://www.rxlist.com/cgi/generic/progesterone.htm
PDRhealth
http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/pro1670.shtml
Drugs.com
http://www.drugs.com/progesterone.html
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