Tìm theo
PRLX 93936
Thuốc Gốc
Small Molecule
PRLX 93936 is selectively toxic to cancer cells.
Dược Lực Học : PRLX 93936 shows robust and selective toxicity in a wide variety of tumor cell-lines, and causes complete tumor regression in mouse xenograft models of fibrosarcoma, pancreatic cancer, ovarian cancer, colon cancer, and melanoma.
Cơ Chế Tác Dụng : PRLX 93936 is selectively toxic to cancer cells. PRLX 93936 appears to inhibit mitochondrial outer membrane protein VDACs (voltage-dependent anion channels) 2 and 3, resulting in an oxidative, non-apoptotic cell death.
Chỉ Định : Investigated for use/treatment in solid tumors.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB06098
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