PRLX 93936

Thuốc Gốc

Small Molecule

PRLX 93936 is selectively toxic to cancer cells.

Dược Lực Học : PRLX 93936 shows robust and selective toxicity in a wide variety of tumor cell-lines, and causes complete tumor regression in mouse xenograft models of fibrosarcoma, pancreatic cancer, ovarian cancer, colon cancer, and melanoma.

Cơ Chế Tác Dụng : PRLX 93936 is selectively toxic to cancer cells. PRLX 93936 appears to inhibit mitochondrial outer membrane protein VDACs (voltage-dependent anion channels) 2 and 3, resulting in an oxidative, non-apoptotic cell death.

Chỉ Định : Investigated for use/treatment in solid tumors.

Tài Liệu Tham Khảo Thêm

drugbank

http://www.drugbank.ca/drugs/DB06098

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