Tìm theo
Prilocaine
Các tên gọi khác (12 ) :
  • 2-(Propylamino)-O-propionotoluidide
  • 2-Methyl-alpha-propylaminopropionanilide
  • alpha-N-Propylamino-2-methylpropionanilide
  • N-(2-Methylphenyl)-2-(propylamino)propanamide
  • O-Methyl-2-propylaminopropionanilide
  • O-Methyl-alpha-propylaminopropionanilide
  • Prilocain
  • Prilocaina
  • Prilocaïne
  • Prilocaine base
  • Prilocainum
  • Propitocaine
Thuốc gây mê
Thuốc Gốc
Small Molecule
CAS: 721-50-6
ATC: N01BB04
ĐG : APP Pharmaceuticals , http://www.apppharma.com
CTHH: C13H20N2O
PTK: 220.3107
A local anesthetic that is similar pharmacologically to lidocaine. Currently, it is used most often for infiltration anesthesia in dentistry. (From AMA Drug Evaluations Annual, 1992, p165)
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C13H20N2O
Phân tử khối
220.3107
Monoisotopic mass
220.157563272
InChI
InChI=1S/C13H20N2O/c1-4-9-14-11(3)13(16)15-12-8-6-5-7-10(12)2/h5-8,11,14H,4,9H2,1-3H3,(H,15,16)
InChI Key
InChIKey=MVFGUOIZUNYYSO-UHFFFAOYSA-N
IUPAC Name
N-(2-methylphenyl)-2-(propylamino)propanamide
Traditional IUPAC Name
prilocaine
SMILES
CCCNC(C)C(=O)NC1=CC=CC=C1C
Độ tan chảy
37-38 °C
Độ sôi
159-162 °C at 1.00E-01 mm Hg
Độ hòa tan
541 mg/L
logP
2.11
logS
-2.8
pKa (strongest acidic)
13.51
pKa (Strongest Basic)
8.82
PSA
41.13 Å2
Refractivity
67.86 m3·mol-1
Polarizability
25.98 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
2
H Bond Donor Count
2
Physiological Charge
1
Number of Rings
1
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Prilocaine binds to the intracellular surface of sodium channels which blocks the subsequent influx of sodium into the cell. Action potential propagation and never function is, therefore, prevented. This block is reversible and when the drug diffuses away from the cell, sodium channel function is restored and nerve propagation returns.
Cơ Chế Tác Dụng : A local anesthetic that is similar pharmacologically to lidocaine. Currently, it is used most often for infiltration anesthesia in dentistry. (From AMA Drug Evaluations Annual, 1992, p165) Prilocaine acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. The antiarrhythmic actions are mediated through effects on sodium channels in Purkinje fibers.
Dược Động Học :

▧ Protein binding :
98%
▧ Route of Elimination :
Prilocaine is metabolized in both the liver and the kidney and excreted via the kidney.
Chỉ Định : Used as a local anaesthetic and is often used in dentistry.
Liều Lượng & Cách Dùng : Solution - Infiltration
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : AstraZeneca
    Sản phẩm biệt dược : Citanest
  • Công ty : Goldshield
    Sản phẩm biệt dược : Prilotekal
  • Công ty : Meduna
    Sản phẩm biệt dược : Takipril
  • Công ty : AstraZeneca
    Sản phẩm biệt dược : Xylonest
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00750
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=4906
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505066
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07531
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00553
ChemSpider
http://www.chemspider.com/Chemical-Structure.4737.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017654
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/66312-520-14
PharmGKB
http://www.pharmgkb.org/drug/PA451101
Wikipedia
http://en.wikipedia.org/wiki/Prilocaine
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