Tìm theo
Pranlukast
Các tên gọi khác (2) :
  • ONO-RS 411
  • SID50126316
Thuốc tác dụng trên đường hô hấp
Thuốc Gốc
Small Molecule
CAS: 103177-37-3
ATC: R03DC02
CTHH: C27H23N5O4
PTK: 481.5026
Pranlukast is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction to accidentally or inadvertently encountered allergens.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C27H23N5O4
Phân tử khối
481.5026
Monoisotopic mass
481.175004249
InChI
InChI=1S/C27H23N5O4/c33-23-17-25(26-29-31-32-30-26)36-24-16-20(11-14-22(23)24)28-27(34)19-9-12-21(13-10-19)35-15-5-4-8-18-6-2-1-3-7-18/h1-3,6-7,9-14,16-17H,4-5,8,15H2,(H,28,34)(H,29,30,31,32)
InChI Key
InChIKey=UAJUXJSXCLUTNU-UHFFFAOYSA-N
IUPAC Name
N-[4-oxo-2-(2H-1,2,3,4-tetrazol-5-yl)-4H-chromen-7-yl]-4-(4-phenylbutoxy)benzamide
Traditional IUPAC Name
pranlukast
SMILES
O=C(NC1=CC2=C(C=C1)C(=O)C=C(O2)C1=NNN=N1)C1=CC=C(OCCCCC2=CC=CC=C2)C=C1
Độ hòa tan
3.00e-03 g/l
logP
4.67
logS
-5.2
pKa (strongest acidic)
5.96
pKa (Strongest Basic)
-2.2
PSA
119.09 Å2
Refractivity
139.15 m3·mol-1
Polarizability
49.7 Å3
Rotatable Bond Count
9
H Bond Acceptor Count
7
H Bond Donor Count
2
Physiological Charge
-1
Number of Rings
5
Bioavailability
1
Rule of Five
true
MDDR-Like Rule
true
Dược Lực Học : Pranlukast is a cysteinyl leukotriene receptor-1 antagonist.
Cơ Chế Tác Dụng : Pranlukast is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction to accidentally or inadvertently encountered allergens. Pranlukast selectively antagonizes leukotriene D4 (LTD4) at the cysteinyl leukotriene receptor, CysLT1, in the human airway. Pranlukast inhibits the actions of LTD4 at the CysLT1 receptor, preventing airway edema, smooth muscle contraction, and enhanced secretion of thick, viscous mucus.
Dược Động Học :

▧ Metabolism :
Hepatic
Độc Tính : Side effects include headache, abdominal or stomach pain, cough, dental pain, dizziness, fever, heartburn, skin rash, stuffy nose, weakness or unusual tiredness.
Chỉ Định : Used as an adjunct to the standard therapy of inhaled steroids with inhaled long- and/or short-acting beta-agonists.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01411
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=115100
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508129
ChemSpider
http://www.chemspider.com/Chemical-Structure.102999.html
PharmGKB
http://www.pharmgkb.org/drug/PA134698661
Wikipedia
http://en.wikipedia.org/wiki/Pranlukast
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