Tìm theo
Polythiazide
Các tên gọi khác (1) :
  • Renese
Thuốc Gốc
Small Molecule
CAS: 346-18-9
ATC: C03AA05
ĐG : Pfizer Inc. , http://www.pfizer.com
CTHH: C11H13ClF3N3O4S3
PTK: 439.882
A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p826)
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C11H13ClF3N3O4S3
Phân tử khối
439.882
Monoisotopic mass
438.970880311
InChI
InChI=1S/C11H13ClF3N3O4S3/c1-18-10(4-23-5-11(13,14)15)17-7-2-6(12)8(24(16,19)20)3-9(7)25(18,21)22/h2-3,10,17H,4-5H2,1H3,(H2,16,19,20)
InChI Key
InChIKey=CYLWJCABXYDINA-UHFFFAOYSA-N
IUPAC Name
6-chloro-2-methyl-1,1-dioxo-3-{[(2,2,2-trifluoroethyl)sulfanyl]methyl}-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide
Traditional IUPAC Name
polythiazide
SMILES
CN1C(CSCC(F)(F)F)NC2=CC(Cl)=C(C=C2S1(=O)=O)S(N)(=O)=O
Độ tan chảy
214 °C
Độ hòa tan
2.64e-01 g/l
logP
1.90
logS
-3.2
pKa (strongest acidic)
9.31
pKa (Strongest Basic)
-3.1
PSA
109.57 Å2
Refractivity
90.52 m3·mol-1
Polarizability
37.56 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
5
H Bond Donor Count
2
Physiological Charge
0
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : As a thiazide diuretic, Polythiazide inhibits the sodium-chloride symporter which decreases solute reabsorption leading to a retention of water in the urine, as water normally follows solutes. More frequent urination is due to the increased loss of water that has not been retained from the body as a result of a concomitant relationship with sodium loss from the convoluted tubule. The short-term anti-hypertensive action is based on the fact that thiazides decrease preload, decreasing blood pressure
Cơ Chế Tác Dụng : A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p826) As a diuretic, polythiazide inhibits active chloride reabsorption at the early distal tubule via the thiazide-sensitive Na-Cl cotransporter (TSC), resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like polythiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of polythiazide may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle.
Chỉ Định : Polythiazide is a thiazide diuretic used to decrease edema and decrease blood pressure.
Tương Tác Thuốc :
  • Digoxin Possible electrolyte variations and arrhythmias
  • Lithium The thiazide diuretic, polythiazide, may increase serum levels of lithium.
  • Trandolapril The thiazide diuretic, Polythiazide, may increase the hypotensive effect of Trandolapril. Polythiazide may also increase the nephrotoxicity of Trandolapril. Monitor for postural hypotension at initiation of concomitant therapy and renal dysfunction during chronic therapy.
  • Treprostinil Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Liều Lượng & Cách Dùng : Tablet - Oral
Dữ Kiện Thương Mại
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01324
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=4870
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508633
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07766
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00657
ChemSpider
http://www.chemspider.com/Chemical-Structure.4704.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0069-3750-66
PharmGKB
http://www.pharmgkb.org/drug/PA164748763
RxList
http://www.rxlist.com/cgi/generic/renese.htm
Drugs.com
http://www.drugs.com/cons/polythiazide.html
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