Tìm theo
Polymyxin B Sulfate
Các tên gọi khác (7 ) :
  • Polimixina B
  • Polymyxin B
  • Polymyxin-B-Sulfat
  • Polymyxine B
  • Polymyxine B (sulfate de)
  • Polymyxini B sulfas
  • Polymyxinum B
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 1405-20-5
ATC: A07AA05, J01XB02, S01AA18, S02AA11, S03AA03
ĐG : Abraxis BioScience Inc. , http://www.abraxisbio.com
CTHH: C56H98N16O13
PTK: 1203.4767
Polymyxin B sulfate is a mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic. All gram-positive bacteria, fungi, and the gram-negative cocci, N. gonorrhea and N. menigitidis, are resistant. It is appropriate for treatment of infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of Pseudomonas aeruginosa.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C56H98N16O13
Phân tử khối
1203.4767
Monoisotopic mass
1202.749927302
InChI
InChI=1S/C56H98N16O13/c1-7-32(4)13-11-12-16-44(75)63-36(17-23-57)51(80)72-46(34(6)74)56(85)68-39(20-26-60)48(77)67-41-22-28-62-55(84)45(33(5)73)71-52(81)40(21-27-61)65-47(76)37(18-24-58)66-53(82)42(29-31(2)3)69-54(83)43(30-35-14-9-8-10-15-35)70-49(78)38(19-25-59)64-50(41)79/h8-10,14-15,31-34,36-43,45-46,73-74H,7,11-13,16-30,57-61H2,1-6H3,(H,62,84)(H,63,75)(H,64,79)(H,65,76)(H,66,82)(H,67,77)(H,68,85)(H,69,83)(H,70,78)(H,71,81)(H,72,80)
InChI Key
InChIKey=WQVJHHACXVLGBL-UHFFFAOYSA-N
IUPAC Name
N-[3-amino-1-({1-[(3-amino-1-{[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl)carbamoyl]-2-hydroxypropyl}carbamoyl)propyl]-6-methyloctanamide
Traditional IUPAC Name
N-[3-amino-1-({1-[(3-amino-1-{[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl)carbamoyl]-2-hydroxypropyl}carbamoyl)propyl]-6-methyloctanamide
SMILES
CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CCN)NC1=O)C(C)O
Độ hòa tan
25 mg/mL
logP
-4.861
logS
-4.2
pKa (strongest acidic)
11.57
pKa (Strongest Basic)
10.23
PSA
490.66 Å2
Refractivity
313.22 m3·mol-1
Polarizability
129.71 Å3
Rotatable Bond Count
29
H Bond Acceptor Count
18
H Bond Donor Count
18
Physiological Charge
5
Number of Rings
2
Bioavailability
0
Dược Lực Học : Polymyxin B sulfate is a mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic. All gram-positive bacteria, fungi, and the gram-negative cocci, N. gonorrhea and N. menigitidis, are resistant.
Cơ Chế Tác Dụng : Polymyxin B sulfate is a mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic. All gram-positive bacteria, fungi, and the gram-negative cocci, N. gonorrhea and N. menigitidis, are resistant. It is appropriate for treatment of infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of Pseudomonas aeruginosa. Polymyxin B sulfate has a bactericidal action against almost all gram-negative bacilli except the Proteus group. Polymyxin B sulfate interacts with the lipopolysaccharide of the cytoplasmic outer membrane of Gram-negative bacteria, altering membrane permeability and causing cell death. It does not need to enter the cell.
Dược Động Học :
▧ Absorption :
Not absorbed from the normal alimentary tract.
▧ Route of Elimination :
The drug is excreted slowly by the kidneys.
Độc Tính : Overdose can cause stomach pains, vomiting, and diarrhea.
Chỉ Định : For treatment of infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of Pseudomonas aeruginosa.
Tương Tác Thuốc :
  • Vecuronium Polymyxin B may increase the neuromuscular blocking action of Vecuronium. Risk of respiratory depression and apnea. Consider alternate therapy or monitor for prolonged neuromuscular blocking effects, such as respiratory paralysis.
Liều Lượng & Cách Dùng : Injection, solution - Intramuscular
Injection, solution - Intravenous drip
Powder, for solution - Intrathecal
Powder, for solution - Ophthalmic
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : GlaxoSmithKline
    Sản phẩm biệt dược : Aerosporin
  • Công ty : Pola Pharma
    Sản phẩm biệt dược : Metamyxin
  • Công ty : Fuji Yakuhin
    Sản phẩm biệt dược : Polomyxin B
  • Công ty : X-Gen
    Sản phẩm biệt dược : Poly-Rx
  • Công ty : Intra
    Sản phẩm biệt dược : Polyfax
  • Công ty : Celon
    Sản phẩm biệt dược : Polyxx
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00781
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=4868
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507302
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C11613
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01066
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/55390-139-10
PharmGKB
http://www.pharmgkb.org/drug/PA451027
Wikipedia
http://en.wikipedia.org/wiki/Polymyxin_B
RxList
http://www.rxlist.com/cgi/generic3/polymyxin.htm
Drugs.com
http://www.drugs.com/mtm/polymyxin-b-ophthalmic.html
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