Tìm theo
polyacrylic acid
tissue adhesives
Thuốc Gốc
Small Molecule
CTHH: C3H4O2
PTK: 72.0627
Polyacrylic acid is developed by ReProtect. It is a gel that may help both block the spread of sexually transmitted diseases and reduce unwanted pregnancies. The compound, known as BufferGel, is currently in advanced clinical trials for its ability to prevent pregnancy.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C3H4O2
Phân tử khối
72.0627
Monoisotopic mass
72.021129372
InChI
InChI=1S/C3H4O2/c1-2-3(4)5/h2H,1H2,(H,4,5)
InChI Key
InChIKey=NIXOWILDQLNWCW-UHFFFAOYSA-N
IUPAC Name
prop-2-enoic acid
Traditional IUPAC Name
acrylic acid
SMILES
OC(=O)C=C
Độ hòa tan
1.23e+02 g/l
logP
0.53
logS
0.23
pKa (strongest acidic)
4.72
PSA
37.3 Å2
Refractivity
17.29 m3·mol-1
Polarizability
6.38 Å3
Rotatable Bond Count
1
H Bond Acceptor Count
2
H Bond Donor Count
1
Physiological Charge
-1
Number of Rings
0
Bioavailability
1
Rule of Five
true
Cơ Chế Tác Dụng : Polyacrylic acid is developed by ReProtect. It is a gel that may help both block the spread of sexually transmitted diseases and reduce unwanted pregnancies. The compound, known as BufferGel, is currently in advanced clinical trials for its ability to prevent pregnancy. BufferGel is a microbicidal spermicide that provides sufficient buffering activity to maintain the mild, protective acidity of the vagina in the presence of semen. Sperm are acid-sensitive, so to assure fertility, semen provides a powerful alkalinizing action that abolishes the protective acidity of the vagina for several hours after intercourse. This alkalinizing action of semen also enables acid-sensitive sexually transmitted diseases (STD) pathogens to transmit infection. By blocking this action of semen, BufferGel prevents unwanted pregnancy, and shows promise for prevention of STDs, including HIV/AIDS.
Chỉ Định : Investigated for use/treatment in contraception and HIV prevention.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : BufferGel
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB05384
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=6581
ChemSpider
http://www.chemspider.com/Chemical-Structure.6333.html
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