Tìm theo
Podofilox
Các tên gọi khác (8 ) :
  • (-)-Podophyllotoxin
  • 9-HYDROXY-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-D][1,3]dioxol-6(5ah)-one
  • Condylox
  • Podofilox
  • Podophyllinic acid lactone
  • Podophyllotoxin
  • Podophyllotoxin 7
  • PPT
Thuốc điều trị ung thư
Thuốc Gốc
Small Molecule
CAS: 518-28-5
ATC: D06BB04
ĐG : DPT Laboratories Ltd. , http://www.dptlabs.com
CTHH: C22H22O8
PTK: 414.4053
A lignan (lignans) found in podophyllin resin from the roots of podophyllum plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C22H22O8
Phân tử khối
414.4053
Monoisotopic mass
414.13146768
InChI
InChI=1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18-,19-,20-/m0/s1
InChI Key
InChIKey=YJGVMLPVUAXIQN-KJYZGMDISA-N
IUPAC Name
(10S,11R,15R,16R)-16-hydroxy-10-(3,4,5-trimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.0³,⁷.0¹¹,¹⁵]hexadeca-1,3(7),8-trien-12-one
Traditional IUPAC Name
(10S,11R,15R,16R)-16-hydroxy-10-(3,4,5-trimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.0³,⁷.0¹¹,¹⁵]hexadeca-1,3(7),8-trien-12-one
SMILES
[H][C@]12COC(=O)[C@]1([H])[C@@H](C1=CC(OC)=C(OC)C(OC)=C1)C1=CC3=C(OCO3)C=C1[C@@H]2O
Độ tan chảy
228 °C
Độ hòa tan
100 mg/L (at 25 °C)
logP
1.5
logS
-3.6
pKa (strongest acidic)
14.02
pKa (Strongest Basic)
-3.2
PSA
92.68 Å2
Refractivity
103.91 m3·mol-1
Polarizability
42 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
7
H Bond Donor Count
1
Physiological Charge
0
Number of Rings
5
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Podofilox, also called podophyllotoxin, is a purer and more stable form of podophyllin in which only the biologically active portion of the compound is present. Podofilox is used to remove certain types of warts on the outside skin of the genital areas.
Cơ Chế Tác Dụng : A lignan (lignans) found in podophyllin resin from the roots of podophyllum plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives. [PubChem] The exact mechanism of action is not well understood. It does appear, however, that it and its derivatives may bind and inhibit topoisomerase II during the late S and early G2 stage. The drug may bind and stabilize the temporary break caused by the enzyme. This disrupts the reparation of the break through which the double-stranded DNA passes, and consequently stops DNA unwinding and replication
Dược Động Học :
▧ Absorption :
Topical application of 0.05 mL of 0.5% podofilox solution to external genitalia did not result in detectable serum levels. Applications of 0.1 to 1.5 mL resulted in peak serum levels of 1 to 17 ng/mL one to two hours after application.
▧ Half Life :
1.0 to 4.5 hours.
Chỉ Định : For treatment of external genital warts (Condyloma acuminatum).
Liều Lượng & Cách Dùng : Liquid - Topical
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Condylox
  • Công ty :
    Sản phẩm biệt dược : Podophyllotoxin
  • Công ty :
    Sản phẩm biệt dược : Podophyllotoxin 7
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01179
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C10871
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0574-0611-05
PharmGKB
http://www.pharmgkb.org/drug/PA450993
Wikipedia
http://en.wikipedia.org/wiki/Podofilox
RxList
http://www.rxlist.com/cgi/generic4/podophyllin.htm
Drugs.com
http://www.drugs.com/cdi/podofilox-gel.html
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