Tìm theo
PMI-001
Thuốc Gốc
Small Molecule
PMI-001 is a stand-alone, disease-modifying, anti-rheumatic drug (DMARD) being developed by Phytomedics Inc. It is an extract of the roots of an undisclosed perennial shrub which interferes with the production of IL-2 and COX-2 proteins, for the potential treatment of autoimmune diseases, such as rheumatoid arthritis, lupus erythematosus and psoriasis.
Dược Lực Học : PMI-001 is a novel, orally bioavailable, small-molecule-based, plant-derived, multi-component disease modifying agent currently being developed for rheumatoid arthritis. Potential applications of this drug candidate beyond rheumatoid arthritis include a wide range of autoimmune disorders including psoriasis, lupus, inflammatory bowel disease (IBD), and multiple sclerosis (MS).
Cơ Chế Tác Dụng : PMI-001 is a stand-alone, disease-modifying, anti-rheumatic drug (DMARD) being developed by Phytomedics Inc. It is an extract of the roots of an undisclosed perennial shrub which interferes with the production of IL-2 and COX-2 proteins, for the potential treatment of autoimmune diseases, such as rheumatoid arthritis, lupus erythematosus and psoriasis. PMI-001 exerts its potent anti-inflammatory and immunosuppressant activities through unique and synergistic modes of action, which involves potent inhibition of several families of pro-inflammatory genes. PMI-001 most likely interferes with the production of IL-2 and COX-2 proteins.
Chỉ Định : Investigated for use/treatment in rheumatoid arthritis.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB05730
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