Tìm theo
Plasmin
Các tên gọi khác (2) :
  • Bovine Fibrinolysin
  • Bovine Plasmin
Thuốc Gốc
Small Molecule
Plasmin (also known as Fibrinolysin) is a bovine enzyme derived from bovine plasma or extracted from bacterial cultures. It is a globular protein with a molecular weight of ~90,000 daltons. Plasmin consists of two polypeptide chains, one light and one heavy, linked by a disulfide bond. The light chain has a molecular weight of approximately 27,000 Da and contains the active center of plasmin; the heavy chain has a molecular weight of approximately 57,000 Da. Plasmin is used as a local healing ointment when combined together with the enzyme deoxyribonuclease I (extracted from bovine pancreas). Plasmin and deoxyribonuclease both act as lytic enzymes. The combination is available as ointment containing 1 BU (Biological Unit) plasmin and 666 BUs desoxyribonuclease per gram. The ointment is marketed by Pfizer under the brand name Fibrolan in a variety of countries (e.g. Switzerland). It is currently not approved in the USA.
Cơ Chế Tác Dụng : Plasmin (also known as Fibrinolysin) is a bovine enzyme derived from bovine plasma or extracted from bacterial cultures. It is a globular protein with a molecular weight of ~90,000 daltons. Plasmin consists of two polypeptide chains, one light and one heavy, linked by a disulfide bond. The light chain has a molecular weight of approximately 27,000 Da and contains the active center of plasmin; the heavy chain has a molecular weight of approximately 57,000 Da. Plasmin is used as a local healing ointment when combined together with the enzyme deoxyribonuclease I (extracted from bovine pancreas). Plasmin and deoxyribonuclease both act as lytic enzymes. The combination is available as ointment containing 1 BU (Biological Unit) plasmin and 666 BUs desoxyribonuclease per gram. The ointment is marketed by Pfizer under the brand name Fibrolan in a variety of countries (e.g. Switzerland). It is currently not approved in the USA. Plasmin attacks and inactivates fibrin molecules occurring in undesirable exudates on the surface of the human body and on human mucosa, e.g., in superficial wounds and burns, while desoxyribonuclease targets and destroys (human) DNA. The combination of the two enzymes has a synergistic effect on necrotic but not on living tissue.
Dược Động Học :

▧ Metabolism :
local inactivation
▧ Half Life :
Almost completely inactivated after 24 hours
Chỉ Định : Plasmin assists with the healing of minor burns, superficial wounds, ulcers, surgical wounds, and superficial hematomas
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Elase
  • Công ty :
    Sản phẩm biệt dược : Fibrolan
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB05254
Wikipedia
http://en.wikipedia.org/wiki/Plasmin
... loading
... loading