Tìm theo
Pivmecillinam
Các tên gọi khác (6 ) :
  • Amdinocillin pivoxil
  • Coactabs
  • Pivmecilinamo
  • Pivmecillinam
  • Pivmecillinamum
  • PMPC
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 32886-97-8
ATC: J01CA08
CTHH: C21H33N3O5S
PTK: 439.569
Pivmecillinam is a mecillinam prodrug, a pivaloyloxymethyl ester of amdinocillin that is well absorbed orally, but broken down to amdinocillin in the intestinal mucosa. It is active against gram-negative organisms and used as for amdinocillin. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C21H33N3O5S
Phân tử khối
439.569
Monoisotopic mass
439.214091871
InChI
InChI=1S/C21H33N3O5S/c1-20(2,3)19(27)29-13-28-18(26)15-21(4,5)30-17-14(16(25)24(15)17)22-12-23-10-8-6-7-9-11-23/h12,14-15,17H,6-11,13H2,1-5H3/b22-12+/t14-,15+,17-/m1/s1
InChI Key
InChIKey=NPGNOVNWUSPMDP-UTEPHESZSA-N
IUPAC Name
{[(2S,5R,6R)-6-[(azepan-1-ylmethylidene)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-2-yl]carbonyloxy}methyl 2,2-dimethylpropanoate
Traditional IUPAC Name
pivmecillinam
SMILES
[H]C(=N[C@@H]1C(=O)N2[C@@H](C(=O)OCOC(=O)C(C)(C)C)C(C)(C)S[C@]12[H])N1CCCCCC1
Độ tan chảy
119 °C
Độ hòa tan
5.26e-02 g/l
logP
2.91
logS
-3.9
pKa (strongest acidic)
13.66
pKa (Strongest Basic)
7.91
PSA
88.51 Å2
Refractivity
113.03 m3·mol-1
Polarizability
47.7 Å3
Rotatable Bond Count
7
H Bond Acceptor Count
5
H Bond Donor Count
0
Physiological Charge
1
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
MDDR-Like Rule
true
Dược Lực Học : Pivmecillinam is a pivaloyloxymethyl ester of amdinocillin that is well absorbed orally, but broken down to amdinocillin in the intestinal mucosa. It is active against gram-negative organisms and used as for amdinocillin.
Cơ Chế Tác Dụng : Pivmecillinam is a mecillinam prodrug, a pivaloyloxymethyl ester of amdinocillin that is well absorbed orally, but broken down to amdinocillin in the intestinal mucosa. It is active against gram-negative organisms and used as for amdinocillin. [PubChem] Pivmecillinam interferes with the biosynthesis of the bacterial cell wall however its activity is slightly different from that of other penicillins and cephalosporins
Dược Động Học :
▧ Absorption :
Well absorbed following oral administration.
Chỉ Định : Used to treat infections due to mecillinam-sensitive organisms such as urinary tract infections, salmonellosis and typhoid fever.
Tương Tác Thuốc :
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Coactabs
  • Công ty :
    Sản phẩm biệt dược : Selexid
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01605
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D02889
PharmGKB
http://www.pharmgkb.org/drug/PA164750167
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