Tìm theo
Pivampicillin
Các tên gọi khác (6 ) :
  • Ampicillin pivaloyloxymethyl ester
  • Pivaloylampicillin
  • Pivaloyloxymethyl ampicillinate
  • Pivampicilina
  • Pivampicilline
  • Pivampicillinum
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 33817-20-8
CTHH: C22H29N3O6S
PTK: 463.547
Pivalate ester analog of ampicillin.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C22H29N3O6S
Phân tử khối
463.547
Monoisotopic mass
463.177706365
InChI
InChI=1S/C22H29N3O6S/c1-21(2,3)20(29)31-11-30-19(28)15-22(4,5)32-18-14(17(27)25(15)18)24-16(26)13(23)12-9-7-6-8-10-12/h6-10,13-15,18H,11,23H2,1-5H3,(H,24,26)/t13-,14-,15+,18-/m1/s1
InChI Key
InChIKey=ZEMIJUDPLILVNQ-ZXFNITATSA-N
IUPAC Name
{[(2S,5R,6R)-6-[(2R)-2-amino-2-phenylacetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-2-yl]carbonyloxy}methyl 2,2-dimethylpropanoate
Traditional IUPAC Name
pivampicillin
SMILES
[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)[C@H](N)C1=CC=CC=C1)C(=O)OCOC(=O)C(C)(C)C
Độ hòa tan
3.54e-02 g/l
logP
2.07
logS
-4.1
pKa (strongest acidic)
11.71
pKa (Strongest Basic)
7.44
PSA
128.03 Å2
Refractivity
116.25 m3·mol-1
Polarizability
47.54 Å3
Rotatable Bond Count
9
H Bond Acceptor Count
5
H Bond Donor Count
2
Physiological Charge
1
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
MDDR-Like Rule
true
Dược Lực Học : Pivampicillin is the pivaloyloxymethyl ester of (the semi-synthetic penicillin) ampicillin. It is an inactive pro-drug, which is converted during its absorption from the gastrointestinal tract to the microbiologically active ampicillin, together with formaldehyde and pivalic acid, by non-specific esterases present in most body tissues. Amounts in excess of 99% of the pivampicillin absorbed are converted to ampicillin within 15 minutes of absorption.
Cơ Chế Tác Dụng : Pivalate ester analog of ampicillin. Ampicillin (the active metabolite of pivampicillin) has a bactericidal action resulting from inhibition of cell wall mucopeptide biosynthesis.
Dược Động Học :
▧ Absorption :
Absorbed following oral administration.
▧ Half Life :
Approximately 1 hour.
Chỉ Định : or the treatment of respiratory tract infections (including acute bronchitis, acute exacerbations of chronic bronchitis and pneumonia); ear, nose and throat infections; gynecological infections; urinary tract infections (including acute uncomplicated gonococcal urethritis) when caused by non penicillinase-producing susceptible strains of the following organisms: gram-positive organisms, e.g., streptococci, pneumococci and staphylococci; gram-negative organisms, e.g., H. influenzae, N. gonorrhoeae, E. coli, P. mirabilis.
Tương Tác Thuốc :
Liều Lượng & Cách Dùng : Tablet - Oral
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Pondocillin
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01604
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=33478
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505340
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C11750
ChemSpider
http://www.chemspider.com/Chemical-Structure.30899.html
PharmGKB
http://www.pharmgkb.org/drug/PA164776912
Wikipedia
http://en.wikipedia.org/wiki/Pivampicillin
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