Tìm theo
Pipobroman
Các tên gọi khác (1) :
  • Vercyte
Thuốc Gốc
Small Molecule
CAS: 54-91-1
ATC: L01AX02
CTHH: C10H16Br2N2O2
PTK: 356.054
An antineoplastic agent that acts by alkylation. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C10H16Br2N2O2
Phân tử khối
356.054
Monoisotopic mass
353.95785306
InChI
InChI=1S/C10H16Br2N2O2/c11-3-1-9(15)13-5-7-14(8-6-13)10(16)2-4-12/h1-8H2
InChI Key
InChIKey=NJBFOOCLYDNZJN-UHFFFAOYSA-N
IUPAC Name
3-bromo-1-[4-(3-bromopropanoyl)piperazin-1-yl]propan-1-one
Traditional IUPAC Name
pipobroman
SMILES
BrCCC(=O)N1CCN(CC1)C(=O)CCBr
Độ tan chảy
> 300 °C
Độ hòa tan
2490 mg/L
logP
0.42
logS
-2.2
pKa (Strongest Basic)
-0.72
PSA
40.62 Å2
Refractivity
69.45 m3·mol-1
Polarizability
28.44 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
2
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
1
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Pipobroman is an antineoplastic agent. Specifically it is a piperazine derivative with a chemical structure close to that of many DNA alkylating agents. Pipobroman has well documented clinical activity against polycythemia vera and essential thrombocythemia.
Cơ Chế Tác Dụng : An antineoplastic agent that acts by alkylation. [PubChem] The mechanism of action is uncertain but pipobroman is thought to alkylate DNA leading to disruption of DNA synthesis and eventual cell death.
Dược Động Học :
▧ Absorption :
Well absorbed from the GI tract.
Độc Tính : Symptoms of overdose include hematologic toxicity, especially with chronic overdosage.
Chỉ Định : For the treatment of polycythaemia vera and refractory chronic myeloid leukaemia.
Tương Tác Thuốc :
Dữ Kiện Thương Mại
Nhà Sản Xuất
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00236
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=4842
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506548
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07362
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00467
ChemSpider
http://www.chemspider.com/Chemical-Structure.4676.html
PharmGKB
http://www.pharmgkb.org/drug/PA164747673
Wikipedia
http://en.wikipedia.org/wiki/Pipobroman
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