Tìm theo
Piperazine
Các tên gọi khác (5 ) :
  • Diethylenediamine
  • Piperazidine
  • Piperazin
  • Piperazine
  • Vermizine (tn)
antinematodal agents
Thuốc Gốc
Small Molecule
CAS: 110-85-0
ATC: P02CB01, R03DA09
ĐG : Amend
CTHH: C4H10N2
PTK: 86.1356
Piperazine is an organic compound that consists of a six-membered ring containing two opposing nitrogen atoms. Piperazine exists as small alkaline deliquescent crystals with a saline taste. Piperazine was introduced to medicine as a solvent for uric acid. When taken into the body the drug is partly oxidized and partly eliminated unchanged. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Piperazine was first introduced as an anthelmintic in 1953. A large number of piperazine compounds have anthelmintic action. Their mode of action is generally by paralysing parasites, which allows the host body to easily remove or expel the invading organism.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C4H10N2
Phân tử khối
86.1356
Monoisotopic mass
86.08439833
InChI
InChI=1S/C4H10N2/c1-2-6-4-3-5-1/h5-6H,1-4H2
InChI Key
InChIKey=GLUUGHFHXGJENI-UHFFFAOYSA-N
IUPAC Name
piperazine
Traditional IUPAC Name
piperazine
SMILES
C1CNCCN1
Độ tan chảy
106 °C
Độ sôi
146 °C
Độ hòa tan
1E+006 mg/L (at 25 °C)
logP
-1.50
logS
1.07
pKa (Strongest Basic)
9.56
PSA
24.06 Å2
Refractivity
25.45 m3·mol-1
Polarizability
9.97 Å3
Rotatable Bond Count
0
H Bond Acceptor Count
2
H Bond Donor Count
2
Physiological Charge
1
Number of Rings
1
Bioavailability
1
Rule of Five
true
pKa
9.73
Dược Lực Học : Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.
Cơ Chế Tác Dụng : Piperazine is an organic compound that consists of a six-membered ring containing two opposing nitrogen atoms. Piperazine exists as small alkaline deliquescent crystals with a saline taste. Piperazine was introduced to medicine as a solvent for uric acid. When taken into the body the drug is partly oxidized and partly eliminated unchanged. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Piperazine was first introduced as an anthelmintic in 1953. A large number of piperazine compounds have anthelmintic action. Their mode of action is generally by paralysing parasites, which allows the host body to easily remove or expel the invading organism. Piperazine is a GABA receptor agonist. Piperzine binds directly and selectively to muscle membrane GABA receptors, presumably causing hyperpolarization of nerve endings, resulting in flaccid paralysis of the worm. While the worm is paralyzed, it is dislodged from the intestinal lumen and expelled live from the body by normal intestinal peristalsis.
Dược Động Học :
▧ Absorption :
Rapidly absorbed from the gastrointestinal tract
▧ Protein binding :
60-70%
▧ Metabolism :
About 25% is metabolized in the liver. Piperazine is nitrosated to form N -mononitrosopiperazine (MNPz) in gastric juice, which is then metabolized to N-nitroso-3-hydroxypyrrolidine (NHPYR).
Độc Tính : LD50 = 5 g/kg (Human, oral). Symptoms of overdose include muscle fatigue, seizures, and difficulty breathing.
Chỉ Định : Used as alternative treatment for ascariasis caused by Ascaris lumbricoides (roundworm) and enterobiasis (oxyuriasis) caused by Enterobius vermicularis (pinworm). It is also used to treat partial intestinal obstruction by the common roundworm, a condition primarily occurring in children.
Liều Lượng & Cách Dùng : Liquid - Oral
Solution / drops - Oral
Syrup - Oral
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Antepar
  • Công ty :
    Sản phẩm biệt dược : Uvilon
  • Công ty :
    Sản phẩm biệt dược : Vermidol
  • Công ty :
    Sản phẩm biệt dược : Vermizine
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00592
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=4837
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507642
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07973
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00807
ChemSpider
http://www.chemspider.com/Chemical-Structure.13835459.html
PharmGKB
http://www.pharmgkb.org/drug/PA450977
Wikipedia
http://en.wikipedia.org/wiki/Piperazine
Drugs.com
http://www.drugs.com/cons/piperazine.html
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