Tìm theo
Pipecuronium
Các tên gọi khác (2) :
  • Pipecurium
  • Pipecuronium
Thuốc giãn cơ và tăng trương lực cơ
Thuốc Gốc
Small Molecule
CAS: 68399-58-6
ATC: M03AC06
CTHH: C35H62N4O4
PTK: 602.8912
Pipecuronium is a piperazinyl androstane derivative which is a non-depolarizing neuromuscular blocking agent.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C35H62N4O4
Phân tử khối
602.8912
Monoisotopic mass
602.477106492
InChI
InChI=1S/C35H62N4O4/c1-24(40)42-32-21-26-9-10-27-28(35(26,4)23-31(32)37-15-19-39(7,8)20-16-37)11-12-34(3)29(27)22-30(33(34)43-25(2)41)36-13-17-38(5,6)18-14-36/h26-33H,9-23H2,1-8H3/q+2/t26-,27+,28-,29-,30-,31-,32-,33-,34-,35-/m0/s1
InChI Key
InChIKey=OWWLUIWOFHMHOQ-XGHATYIMSA-N
IUPAC Name
4-[(1S,2S,4S,5S,7S,10R,11S,13S,14R,15S)-5,14-bis(acetyloxy)-4-(4,4-dimethylpiperazin-4-ium-1-yl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-13-yl]-1,1-dimethylpiperazin-1-ium
Traditional IUPAC Name
pipecuronium
SMILES
[H][C@@]12C[C@@H]([C@H](OC(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])C[C@H](OC(C)=O)[C@H](C[C@]12C)N1CC[N+](C)(C)CC1)N1CC[N+](C)(C)CC1
Độ hòa tan
9.50e-05 g/l
logP
-5.3
logS
-6.8
pKa (Strongest Basic)
5.31
PSA
59.08 Å2
Refractivity
193.04 m3·mol-1
Polarizability
72.22 Å3
Rotatable Bond Count
6
H Bond Acceptor Count
4
H Bond Donor Count
0
Physiological Charge
2
Number of Rings
6
Bioavailability
1
MDDR-Like Rule
true
Dược Lực Học : Pipecuronium is a nondepolarizing neuromuscular blocking agent. Neuromuscular blocking agents produce skeletal muscle paralysis by blocking neural transmission at the myoneural junction. The paralysis is selective initially and usually appears in the following muscles consecutively: levator muscles of eyelids, muscles of mastication, limb muscles, abdominal muscles, muscles of the glottis, and finally, the intercostal muscles and the diaphragm. Neuromuscular blocking agents have no clinically significant effect on consciousness or the pain threshold.
Cơ Chế Tác Dụng : Pipecuronium is a piperazinyl androstane derivative which is a non-depolarizing neuromuscular blocking agent. Nondepolarizing neuromuscular blocking agents inhibit neuromuscular transmission by competing with acetylcholine for the cholinergic receptors of the motor end plate, thereby reducing the response of the end plate to acetylcholine. This type of neuromuscular block is usually antagonized by anticholinesterase agents.
Dược Động Học :

▧ Half Life :
Distribution Normal renal function: 6.22 (range, 1.34 to 10.66) minutes. Renal function impairment: 4.33 (range, 1.69 to 6.17) minutes. Elimination Normal renal function: 1.7 (range, 0.9 to 2.7) hours. The elimination half-life is not altered by hypothermia and bypass. Renal function impairment: 4 (range, 2 to 8.2) hours. [PharmGKB]
Chỉ Định : Used as a muscle relaxant during anesthesia and surgical procedures.
Tương Tác Thuốc :
  • Amikacin The agent increases the effect of muscle relaxant
  • Clindamycin The agent increases the effect of muscle relaxant
  • Gentamicin The agent increases the effect of muscle relaxant
  • Lincomycin The agent increases the effect of muscle relaxant
  • Netilmicin The agent increases the effect of muscle relaxant
  • Piperacillin The agent increases the effect of the muscle relaxant
  • Tobramycin The agent increases the effect of the muscle relaxant
Liều Lượng & Cách Dùng : Solution - Intravenous
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Arduan
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01338
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=50192
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508493
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07554
ChemSpider
http://www.chemspider.com/Chemical-Structure.45517.html
PharmGKB
http://www.pharmgkb.org/drug/PA164764567
Wikipedia
http://en.wikipedia.org/wiki/Pipecuronium
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