Tìm theo
pimagedine HCl
Thuốc Gốc
Small Molecule
CTHH: CH7ClN4
PTK: 110.546
It has been developed by Synvista Therapeutics, Inc for the treatment of diabetic kidney disease.Pimagedine HCl is an advanced glycation end products inhibitor which manages diabetic nephropathy, either alone or in combination with other therapies. It is beneficial in treating patients with diabetic nephropathy.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
CH7ClN4
Phân tử khối
110.546
Monoisotopic mass
110.035923951
InChI
InChI=1S/CH6N4.ClH/c2-1(3)5-4;/h4H2,(H4,2,3,5);1H
InChI Key
InChIKey=UBDZFAGVPPMTIT-UHFFFAOYSA-N
IUPAC Name
2-azaniumylguanidine chloride
Traditional IUPAC Name
2-aminioguanidine chloride
SMILES
[Cl-].NC(N)=N[NH3+]
Độ hòa tan
3.28e+01 g/l
logP
-1.5
logS
-0.53
pKa (Strongest Basic)
10.77
PSA
92.04 Å2
Refractivity
30.16 m3·mol-1
Polarizability
7.32 Å3
Rotatable Bond Count
0
H Bond Acceptor Count
3
H Bond Donor Count
3
Physiological Charge
1
Number of Rings
0
Bioavailability
1
Rule of Five
true
Cơ Chế Tác Dụng : It has been developed by Synvista Therapeutics, Inc for the treatment of diabetic kidney disease.Pimagedine HCl is an advanced glycation end products inhibitor which manages diabetic nephropathy, either alone or in combination with other therapies. It is beneficial in treating patients with diabetic nephropathy. Pimagedine reportedly inhibits the formation of glycosylated proteins (advanced glycosylation end-products) and has other actions including inhibition of aldose reductase.
Chỉ Định : Investigated for use/treatment in diabetic kidney disease.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB05383
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=16017
ChemSpider
http://www.chemspider.com/Chemical-Structure.15211.html
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