Tìm theo
Picoplatin
Các tên gọi khác (1) :
  • (SP-4-3)-Amminedichloro(2-methylpyridine)platinium
Thuốc điều trị ung thư
Thuốc Gốc
Small Molecule
CAS: 181630-15-9
CTHH: C6H10Cl2N2Pt
PTK: 376.147
Picoplatin is a cytotoxic platinum compound in clinical development for the treatment of patients with solid tumors. It causes apoptosis (cell death) by binding to DNA and interfering with DNA replication and transcription.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C6H10Cl2N2Pt
Phân tử khối
376.147
Monoisotopic mass
374.986878193
InChI
InChI=1S/C6H7N.2ClH.H3N.Pt/c1-6-4-2-3-5-7-6;;;;/h2-5H,1H3;2*1H;1H3;/q;;;;+2/p-2
InChI Key
InChIKey=IIMIOEBMYPRQGU-UHFFFAOYSA-L
IUPAC Name
platinum(2+) ion 2-methylpyridine amine dichloride
Traditional IUPAC Name
platinum(2+) picoline amine dichloride
SMILES
N.[Cl-].[Cl-].[Pt++].CC1=CC=CC=N1
logP
0.89
pKa (Strongest Basic)
5.81
PSA
12.89 Å2
Refractivity
28.49 m3·mol-1
Polarizability
10.39 Å3
Rotatable Bond Count
0
H Bond Acceptor Count
1
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
1
Bioavailability
1
Rule of Five
true
Dược Lực Học : Picoplatin is a sterically hindered platinum (II) complex designed to deliver an extended spectrum of anti-cancer activity and overcome platinum resistance.
Cơ Chế Tác Dụng : Picoplatin is a cytotoxic platinum compound in clinical development for the treatment of patients with solid tumors. It causes apoptosis (cell death) by binding to DNA and interfering with DNA replication and transcription. Picoplatin causes apoptosis (cell death) by binding to DNA and interfering with DNA replication and transcription.
Chỉ Định : For the treatment of patients with solid tumors.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB04874
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=177358
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=10258599
ChemSpider
http://www.chemspider.com/Chemical-Structure.154428.html
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