Tìm theo
Phensuximide
Các tên gọi khác (5 ) :
  • Fensuccimide
  • Fensuximida
  • Milontin
  • Phensuximide
  • Phensuximidum
Thuốc chống co giật, chống động kinh
Thuốc Gốc
Small Molecule
CAS: 86-34-0
ATC: N03AD02
CTHH: C11H11NO2
PTK: 189.2105
Phensuximide is an anticonvulsant in the succinimide class. It suppresses the paroxysmal three cycle per second spike and wave EEG pattern associated with lapses of consciousness in petit mal seizures. The frequency of attacks is reduced by depression of nerve transmission in the motor cortex.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C11H11NO2
Phân tử khối
189.2105
Monoisotopic mass
189.078978601
InChI
InChI=1S/C11H11NO2/c1-12-10(13)7-9(11(12)14)8-5-3-2-4-6-8/h2-6,9H,7H2,1H3
InChI Key
InChIKey=WLWFNJKHKGIJNW-UHFFFAOYSA-N
IUPAC Name
1-methyl-3-phenylpyrrolidine-2,5-dione
Traditional IUPAC Name
phensuximide
SMILES
CN1C(=O)CC(C1=O)C1=CC=CC=C1
Độ tan chảy
72 °C
Độ hòa tan
7020 mg/L
logP
0.7
logS
-1.9
pKa (strongest acidic)
19.4
pKa (Strongest Basic)
-7.4
PSA
37.38 Å2
Refractivity
51.85 m3·mol-1
Polarizability
19.66 Å3
Rotatable Bond Count
1
H Bond Acceptor Count
2
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Phensuximide suppresses the paroxysmal three cycle per second spike and wave EEG pattern associated with lapses of consciousness in absence (petit mal) seizures. The frequency of attacks is reduced by depression of nerve transmission in the motor cortex.
Cơ Chế Tác Dụng : Phensuximide is an anticonvulsant in the succinimide class. It suppresses the paroxysmal three cycle per second spike and wave EEG pattern associated with lapses of consciousness in petit mal seizures. The frequency of attacks is reduced by depression of nerve transmission in the motor cortex. Phensuximide's mechanism of action not understood, but may act in inhibitory neuronal systems that are important in the generation of the three per second rhythm. It's effects may be related to its ability to inhibit depolarization-induced accumulation of cyclic AMP and cyclic GMP in brain tissue.
Dược Động Học :
▧ Absorption :
Rapid and complete.
▧ Protein binding :
21%
▧ Metabolism :
Hepatic.
Chỉ Định : For the treatment of epilepsy.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty : Debat
    Sản phẩm biệt dược : Lifene
  • Công ty : Parke-Davis
    Sản phẩm biệt dược : Milontin
  • Công ty : BCM Corporation
    Sản phẩm biệt dược : Milonton
  • Công ty : Katwijk
    Sản phẩm biệt dược : Succitimal
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00832
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=6839
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505695
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07437
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00508
ChemSpider
http://www.chemspider.com/Chemical-Structure.6578.html
PharmGKB
http://www.pharmgkb.org/drug/PA164771230
Wikipedia
http://en.wikipedia.org/wiki/Phensuximide
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