Tìm theo
Phenol
Các tên gọi khác (16 ) :
  • Acide carbolique
  • Acide phenique
  • Benzenol
  • Carbolic acid
  • Carbolsaeure
  • Hydroxybenzene
  • Karbolsaeure
  • Monohydroxybenzene
  • Oxybenzene
  • Phenic Acid
  • Phenol
  • Phenyl alcohol
  • Phenyl hydroxide
  • Phenylic Acid
  • Phenylic alcohol
  • PHOH
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 108-95-2
ATC: N01BX03, C05BB05, R02AA19, D08AE03
ĐG : ALK-Abello Inc. , http://www.alk-abello.com
CTHH: C6H6O
PTK: 94.1112
Phenol is an antiseptic and disinfectant. It is active against a wide range of micro-organisms including some fungi and viruses, but is only slowly effective against spores. Phenol has been used to disinfect skin and to relieve itching. Phenol is also used as an oral analgesic or anesthetic in products such as Chloraseptic to treat pharyngitis. Additionally, phenol and its related compounds are used in surgical ingrown toenail treatment, a process termed phenolization. Research indicates that parental exposure to phenol and its related compounds are positively associated with spontaneous abortion. During the second world war, phenol injections were used as a means of execution by the Nazis. Phenol is a toxic compound whose vapours are corrosive to the skin, eyes, and respiratory tract.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C6H6O
Phân tử khối
94.1112
Monoisotopic mass
94.041864814
InChI
InChI=1S/C6H6O/c7-6-4-2-1-3-5-6/h1-5,7H
InChI Key
InChIKey=ISWSIDIOOBJBQZ-UHFFFAOYSA-N
IUPAC Name
phenol
Traditional IUPAC Name
phenol
SMILES
OC1=CC=CC=C1
Độ tan chảy
40.9 °C
Độ sôi
181.8 °C
Độ hòa tan
8.28E+004 mg/L (at 25 °C)
logP
1.46
pKa (strongest acidic)
10.02
pKa (Strongest Basic)
-5.5
PSA
20.23 Å2
Refractivity
28.04 m3·mol-1
Polarizability
9.81 Å3
logS
0
Rotatable Bond Count
0
H Bond Acceptor Count
1
H Bond Donor Count
1
Physiological Charge
0
Number of Rings
1
Bioavailability
1
Rule of Five
true
pKa
9.99 (at 25 °C)
Cơ Chế Tác Dụng : Phenol is an antiseptic and disinfectant. It is active against a wide range of micro-organisms including some fungi and viruses, but is only slowly effective against spores. Phenol has been used to disinfect skin and to relieve itching. Phenol is also used as an oral analgesic or anesthetic in products such as Chloraseptic to treat pharyngitis. Additionally, phenol and its related compounds are used in surgical ingrown toenail treatment, a process termed phenolization. Research indicates that parental exposure to phenol and its related compounds are positively associated with spontaneous abortion. During the second world war, phenol injections were used as a means of execution by the Nazis. Phenol is a toxic compound whose vapours are corrosive to the skin, eyes, and respiratory tract. Phenol is a potent proteolytic agent. Concentrations in the 5% to 7% range dissolve tissue on contact via proteolysis. In high concentrations when injected next to a nerve, phenol produces a chemical neurolysis which is nonselective across nerve fiber size and most prominent on its outer aspect. Local anesthetic effects occur within 5-10 minutes.
Dược Động Học :
▧ Absorption :
Phenol is rapidly absorbed through the skin and into the lungs.
▧ Volume of Distribution :
At I5 min after exposure, the liver contained the highest level of phenol, consisting mainly of free phenol. After 82 minutes post administration, phenol is uniformly distributed in the liver, blood, kidneys, lungs, along with the heart, testes, thymus and the spleen. With the passage of time, the proportion of free to conjugated phenol changed. By 360 minutes most phenol appears in conjugated forms.
▧ Metabolism :
Phenyl sulfate, phenyl glucuronide, quinol sulfate, and quinol glucuronide were detected in human beings as phenol metabolites.
▧ Route of Elimination :
The kidney is the primary route of elimination of phenol.
▧ Clearance :
In rabbits, 72% is excreted in the urine, 1% in the feces, 4% in the carcass following sacrifice, and trace amounts were exhaled.
Độc Tính : Mouse, Subcutaneous, LD50: 0.3-0.35 g/kg. (Duplay and Cazin, 1891; Tollens, 1905). Rat, Subcutaneous, LD50: 0.45. (Deichmann and Witherup, 1944). Rat, Oral, LD50: 0.53. (Deichmann and Witherup, 1944). Rat, Oral, LD50: 0.65. (Flickinger, 1976). Rat, Cutaneous, LD50: 0.67. (Conning and Hayes, 1970).
Chỉ Định : Phenol is primarily indicated for minor sore throat pain, sore mouth, minor mouth irritation, and pain associated with canker sores. Additionally, phenol is indicated in the treatment of focal spasticity.
Dữ Kiện Thương Mại
Nhà Sản Xuất
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB03255
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=996
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508193
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C00146
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00033
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26187
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/67172-112-31
PharmGKB
http://www.pharmgkb.org/drug/PA450913
Wikipedia
http://en.wikipedia.org/wiki/Phenol
Drugs.com
http://www.drugs.com/cdi/phenol-spray.html
... loading
... loading