Tìm theo
Pheniramine
Các tên gọi khác (4 ) :
  • Feniramina
  • Pheniramine
  • Pheniraminum
  • SID90341510
Thuốc chống dị ứng
Thuốc Gốc
Small Molecule
CAS: 86-21-5
ATC: R06AB05
CTHH: C16H20N2
PTK: 240.3434
One of the histamine H1 antagonists with little sedative action. It is used in treatment of hay fever, rhinitis, allergic dermatoses, and pruritus. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C16H20N2
Phân tử khối
240.3434
Monoisotopic mass
240.16264865
InChI
InChI=1S/C16H20N2/c1-18(2)13-11-15(14-8-4-3-5-9-14)16-10-6-7-12-17-16/h3-10,12,15H,11,13H2,1-2H3
InChI Key
InChIKey=IJHNSHDBIRRJRN-UHFFFAOYSA-N
IUPAC Name
dimethyl[3-phenyl-3-(pyridin-2-yl)propyl]amine
Traditional IUPAC Name
pheniramine
SMILES
CN(C)CCC(C1=CC=CC=C1)C1=CC=CC=N1
Độ tan chảy
< 25 °C
Độ sôi
181 °C at 1.30E+01 mm Hg
Độ hòa tan
3.77e-01 g/l
logP
2.98
logS
-2.8
pKa (Strongest Basic)
9.48
PSA
16.13 Å2
Refractivity
76.05 m3·mol-1
Polarizability
28.41 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
2
H Bond Donor Count
0
Physiological Charge
1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Pheniramine is an antihistamine used to treat allergic conditions such as hay fever or urticaria. It is generally sold in combination with other medications, rather than as a stand-alone drug. Allergies are caused by an excessive type 1 hypersensitivity response of the body to allergens, mediated by inappropriate histamine signalling. By inhibiting the binding of histamine, antihistamines decrease the normal histamine response from cells, consequently decreasing allergic symptoms.
Cơ Chế Tác Dụng : One of the histamine H1 antagonists with little sedative action. It is used in treatment of hay fever, rhinitis, allergic dermatoses, and pruritus. [PubChem] Antihistamines such as pheniramine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving histamine release. Antihistamines suppress the histamine-induced wheal (swelling) and flare (vasodilation) response by blocking the binding of histamine to its receptors on nerves, vascular smooth muscle, glandular cells, endothelium, and mast cells. They effectively exert competitive antagonism of histamine for H1-receptors.
Dược Động Học :

▧ Metabolism :
Hepatic hydroxylation, demethylation and glucuronidation.
Chỉ Định : Pheniramine is an antihistamine used to treat allergic conditions such as hay fever or urticaria.
Liều Lượng & Cách Dùng : Powder - Oral
Solution - Oral
Solution / drops - Oral
Tablet - Oral
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : AVIL
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01620
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=4761
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505932
ChemSpider
http://www.chemspider.com/Chemical-Structure.4597.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017656
PharmGKB
http://www.pharmgkb.org/drug/PA164744506
Wikipedia
http://en.wikipedia.org/wiki/Pheniramine
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