Tìm theo
Phencyclidine
Các tên gọi khác (2) :
  • 1-(1-Phenylcyclohexyl)piperidine
  • PCP
enzyme inhibitors, hallucinogens, excitatory amino acid antagonists
Thuốc Gốc
Small Molecule
CAS: 77-10-1
CTHH: C17H25N
PTK: 243.3871
A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to ketamine in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (receptors, N-methyl-D-aspartate). As a drug of abuse, it is known as PCP and Angel Dust. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C17H25N
Phân tử khối
243.3871
Monoisotopic mass
243.198699805
InChI
InChI=1S/C17H25N/c1-4-10-16(11-5-1)17(12-6-2-7-13-17)18-14-8-3-9-15-18/h1,4-5,10-11H,2-3,6-9,12-15H2
InChI Key
InChIKey=JTJMJGYZQZDUJJ-UHFFFAOYSA-N
IUPAC Name
1-(1-phenylcyclohexyl)piperidine
Traditional IUPAC Name
phencyclidine
SMILES
C1CCN(CC1)C1(CCCCC1)C1=CC=CC=C1
Độ tan chảy
46.5 °C
Độ sôi
136 °C at 1.00E+00 mm Hg
Độ hòa tan
3.25e-03 g/l
logP
4.69
logS
-4.9
pKa (Strongest Basic)
10.64
PSA
3.24 Å2
Refractivity
77.65 m3·mol-1
Polarizability
29.66 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
1
H Bond Donor Count
0
Physiological Charge
1
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
caco2 Permeability
-4.61
pKa
8.29
Dược Lực Học : Phencyclidine works primarily as an NMDA receptor antagonist, which blocks the activity of the NMDA Receptor.
Cơ Chế Tác Dụng : A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to ketamine in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (receptors, N-methyl-D-aspartate). As a drug of abuse, it is known as PCP and Angel Dust. [PubChem] The N-methyl-D-Aspartate (NMDA) receptor, a type of ionotropic receptor, is found on the dendrites of neurons and receives signals in the form of neurotransmitters. It is a major excitatory receptor in the brain. Normal physiological function requires that the activated receptor fluxes positive ions through the channel part of the receptor. PCP enters the ion channel from the outside of the neuron and binds, reversibly, to a site in the channel pore, blocking the flux of positive ions into the cell. PCP therefore inhibits depolarization of neurons and interferes with cognitive and other functions of the nervous system. [Wikipedia]
Tương Tác Thuốc :
  • Telithromycin Telithromycin may reduce clearance of Phencyclidine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Phencyclidine if Telithromycin is initiated, discontinued or dose changed.
  • Voriconazole Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of phencyclidine by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of phencyclidine if voriconazole is initiated, discontinued or dose changed.
Dữ Kiện Thương Mại
Nhà Sản Xuất
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB03575
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=6468
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508889
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07575
ChemSpider
http://www.chemspider.com/Chemical-Structure.6224.html
PharmGKB
http://www.pharmgkb.org/drug/PA128406980
Wikipedia
http://en.wikipedia.org/wiki/Phencyclidine
Drugs.com
http://www.drugs.com/phencyclidine.html
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