Tìm theo
Phenacetin
Các tên gọi khác (4 ) :
  • Acetophenetidin
  • Acetophenetidine
  • Acetophenetin
  • Acetphenetidin
analgesics non narcotic
Thuốc Gốc
Small Molecule
CAS: 62-44-2
ATC: N02BE03
CTHH: C10H13NO2
PTK: 179.2157
Phenacetin was withdrawn from the Canadian market in June 1973 due to concerns regarding nephropathy (damage to or disease of the kidney).
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C10H13NO2
Phân tử khối
179.2157
Monoisotopic mass
179.094628665
InChI
InChI=1S/C10H13NO2/c1-3-13-10-6-4-9(5-7-10)11-8(2)12/h4-7H,3H2,1-2H3,(H,11,12)
InChI Key
InChIKey=CPJSUEIXXCENMM-UHFFFAOYSA-N
IUPAC Name
N-(4-ethoxyphenyl)acetamide
Traditional IUPAC Name
phenacetin
SMILES
CCOC1=CC=C(NC(C)=O)C=C1
Độ tan chảy
137.5 °C
Độ hòa tan
766 mg/L (at 25 °C)
logP
1.58
logS
-2.37
pKa (strongest acidic)
14.98
pKa (Strongest Basic)
-4.2
PSA
38.33 Å2
Refractivity
52.13 m3·mol-1
Polarizability
19.82 Å3
Rotatable Bond Count
3
H Bond Acceptor Count
2
H Bond Donor Count
1
Physiological Charge
0
Number of Rings
1
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Phenacetin was the first NSAID and fever reducer to go on the market. Its analgesic effects are due to its actions on the sensory tracts of the spinal cord. In addition, phenacetin has a depressant action of the heart, where it acts as a negative inotrope. It is an antipyretic, acting on the brain to decrease the temperature set point. It is also used to treat rheumatoid arthritis (subacute type), intercostal neuralgia, and some forms of ataxia. [Wikipedia]
Cơ Chế Tác Dụng : Phenacetin was withdrawn from the Canadian market in June 1973 due to concerns regarding nephropathy (damage to or disease of the kidney). Phenacetin's analgesic effects are due to its actions on the sensory tracts of the spinal cord. In addition, phenacetin has a depressant action on the heart, where it acts as a negative inotrope. It is an antipyretic, acting on the brain to decrease the temperature set point. It is also used to treat rheumatoid arthritis (subacute type) and intercostal neuralgia. [Wikipedia]
Dược Động Học :

▧ Metabolism :
Metabolised in the body to paracetamol.
Độc Tính : Acute oral toxicity (LD50): 866 mg/kg [Mouse].
Chỉ Định : Used principally as an analgesic.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Achrocidin
  • Công ty :
    Sản phẩm biệt dược : Codempiral
  • Công ty :
    Sản phẩm biệt dược : Commotional
  • Công ty :
    Sản phẩm biệt dược : Contradol
  • Công ty :
    Sản phẩm biệt dược : Contradouleur
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB03783
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=4754
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507394
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07591
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00569
ChemSpider
http://www.chemspider.com/Chemical-Structure.4590.html
PharmGKB
http://www.pharmgkb.org/drug/PA450897
Wikipedia
http://en.wikipedia.org/wiki/Phenacetin
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