Tìm theo
Phenacemide
Các tên gọi khác (1) :
  • Phenurone
Thuốc Gốc
Small Molecule
CAS: 63-98-9
ATC: N03AX07
CTHH: C9H10N2O2
PTK: 178.1879
Phenacemide is used to control certain seizures in the treatment of epilepsy. This medicine acts on the central nervous system (CNS) to reduce the number and severity of seizures.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C9H10N2O2
Phân tử khối
178.1879
Monoisotopic mass
178.074227574
InChI
InChI=1S/C9H10N2O2/c10-9(13)11-8(12)6-7-4-2-1-3-5-7/h1-5H,6H2,(H3,10,11,12,13)
InChI Key
InChIKey=XPFRXWCVYUEORT-UHFFFAOYSA-N
IUPAC Name
(2-phenylacetyl)urea
Traditional IUPAC Name
2-phenylacetylurea
SMILES
NC(=O)NC(=O)CC1=CC=CC=C1
Độ tan chảy
215 °C
Độ hòa tan
10.2 g/L
logP
0.87
logS
-2.2
pKa (strongest acidic)
11.75
pKa (Strongest Basic)
-7.8
PSA
72.19 Å2
Refractivity
47.43 m3·mol-1
Polarizability
17.49 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
2
H Bond Donor Count
2
Physiological Charge
0
Number of Rings
1
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Phenacemide is a ureal anticonvulsant indicated for control of severe epilepsy, particularly mixed forms of complex partial (psychomotor or temporal lobe) seizures, refractory to other anticonvulsants. Phenacemide elevates the threshold for minimal electroshock convulsions and abolishes the tonic phase of maximal electroshock seizures. It also prevents or modifies seizures induced by pentylenetetrazol or other convulsants.
Cơ Chế Tác Dụng : Phenacemide is used to control certain seizures in the treatment of epilepsy. This medicine acts on the central nervous system (CNS) to reduce the number and severity of seizures. Phenacemide binds to and blocks neuronal sodium channels or voltage sensitive calcium channels. This blocks or suppresses neuronal depolarization and hypersynchronization. Hypersynchronization is what often causes seizures.
Dược Động Học :
▧ Absorption :
Almost completely absorbed.
▧ Metabolism :
Metabolized in the liver by hepatic microsomal enzymes, where it is inactivated by p-hydroxylation.
▧ Half Life :
22-25 hours.
Độc Tính : Oral, mouse: LD50 = 987 mg/kg; Oral, rabbit: LD50 = 2500 mg/kg; Oral, rat: LD50 = 1600 mg/kg
Chỉ Định : Used to control certain seizures in the treatment of epilepsy.
Liều Lượng & Cách Dùng : Tablet - Oral
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Phenurone
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01121
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=4753
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508400
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07428
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00504
ChemSpider
http://www.chemspider.com/Chemical-Structure.4589.html
PharmGKB
http://www.pharmgkb.org/drug/PA164745309
Wikipedia
http://en.wikipedia.org/wiki/Phenacemide
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