Tìm theo
Peramivir
Thuốc Gốc
Small Molecule
CAS: 229614-55-5
CTHH: C15H28N4O4
PTK: 328.4072
Peramivir is an experimental antiviral drug being developed by Biocryst Pharmaceuticals to treat influenza A/B. The development of peramivir is supported by the US Department of Health and Human Services as part of the government's effort to prepare for a flu pandemic. The drug has had a long history. An oral formulation was abandoned by Johnson and Johnson due to poor bioavailability. BioCryst is now developing a injectable version, in partnership with Green Cross Pharmaceuticals in South Korea and with Shionogi Pharmaceuticals in Japan. The drug is in Phase II studies.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C15H28N4O4
Phân tử khối
328.4072
Monoisotopic mass
328.211055404
InChI
InChI=1S/C15H28N4O4/c1-4-8(5-2)12(18-7(3)20)11-10(19-15(16)17)6-9(13(11)21)14(22)23/h8-13,21H,4-6H2,1-3H3,(H,18,20)(H,22,23)(H4,16,17,19)/t9-,10+,11+,12?,13+/m0/s1
InChI Key
InChIKey=XRQDFNLINLXZLB-GKWMMFDUSA-N
IUPAC Name
(1S,2S,3S,4R)-4-[(diaminomethylidene)amino]-3-(1-acetamido-2-ethylbutyl)-2-hydroxycyclopentane-1-carboxylic acid
Traditional IUPAC Name
peramivir
SMILES
CCC(CC)C(NC(C)=O)[C@@H]1[C@H](O)[C@H](C[C@H]1N=C(N)N)C(O)=O
Độ hòa tan
7.05e-01 g/l
logP
-2.2
logS
-2.7
pKa (strongest acidic)
4.18
pKa (Strongest Basic)
11.7
PSA
151.03 Å2
Refractivity
84.17 m3·mol-1
Polarizability
35.16 Å3
Rotatable Bond Count
7
H Bond Acceptor Count
7
H Bond Donor Count
5
Physiological Charge
0
Number of Rings
1
Bioavailability
1
Rule of Five
true
Cơ Chế Tác Dụng : Peramivir is an experimental antiviral drug being developed by Biocryst Pharmaceuticals to treat influenza A/B. The development of peramivir is supported by the US Department of Health and Human Services as part of the government's effort to prepare for a flu pandemic. The drug has had a long history. An oral formulation was abandoned by Johnson and Johnson due to poor bioavailability. BioCryst is now developing a injectable version, in partnership with Green Cross Pharmaceuticals in South Korea and with Shionogi Pharmaceuticals in Japan. The drug is in Phase II studies. Peramivir is a neuraminidase inhibitor, acting as a transition-state analogue inhibitor of influenza neuraminidase and thereby preventing new viruses from emerging from infected cells.
Chỉ Định : Investigated for use/treatment in influenza.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB06614
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=151164
ChemSpider
http://www.chemspider.com/Chemical-Structure.133234.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50092139
Wikipedia
http://en.wikipedia.org/wiki/Peramivir
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