Tìm theo
Pentosan Polysulfate
Các tên gọi khác (5 ) :
  • Pentosan sulfuric polyester
  • Pentosane polysulfate
  • Pentosani polysulfas
  • Pentosano polisulfato
  • Pentosanpolysulfat
Thuốc tác dụng lên quá trình đông máu
Thuốc Gốc
Small Molecule
CAS: 37300-21-3
ATC: C05BA04
ĐG : Alza Corp.
CTHH: C10H18O21S4
PTK: 602.497
A sulfated pentosyl polysaccharide with heparin-like properties. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C10H18O21S4
Phân tử khối
602.497
Monoisotopic mass
601.922340398
InChI
InChI=1S/C10H18O21S4/c11-3-1-26-10(8(31-35(22,23)24)5(3)28-32(13,14)15)27-4-2-25-9(12)7(30-34(19,20)21)6(4)29-33(16,17)18/h3-12H,1-2H2,(H,13,14,15)(H,16,17,18)(H,19,20,21)(H,22,23,24)/t3-,4-,5+,6+,7-,8-,9-,10+/m1/s1
InChI Key
InChIKey=FCCNSUIJIOOXEZ-SJYYZXOBSA-N
IUPAC Name
[(2S,3R,4S,5R)-5-hydroxy-2-{[(3R,4S,5R,6R)-6-hydroxy-4,5-bis(sulfooxy)oxan-3-yl]oxy}-4-(sulfooxy)oxan-3-yl]oxidanesulfonic acid
Traditional IUPAC Name
pentosan polysulfate
SMILES
O[C@@H]1CO[C@@H](O[C@@H]2CO[C@@H](O)[C@H](OS(O)(=O)=O)[C@H]2OS(O)(=O)=O)[C@H](OS(O)(=O)=O)[C@H]1OS(O)(=O)=O
Độ hòa tan
3.49e+00 g/l
logP
-8
logS
-2.2
pKa (strongest acidic)
-2.9
pKa (Strongest Basic)
-3.6
PSA
322.55 Å2
Refractivity
96.38 m3·mol-1
Polarizability
46.17 Å3
Rotatable Bond Count
10
H Bond Acceptor Count
17
H Bond Donor Count
6
Physiological Charge
-4
Number of Rings
2
Bioavailability
0
Dược Lực Học : Pentosan polysulfate sodium is a low molecular weight heparin-like compound. It has anticoagulant and fibrinolytic effects.
Cơ Chế Tác Dụng : A sulfated pentosyl polysaccharide with heparin-like properties. [PubChem] Pentosan polysulfate is a polymer of xylose hydrogen sulfate and contains two sulfate groups per carbohydrate monomer. It binds Fibroblast growth factors (FGFs) as well as other heparin-binding growth factors. It has been shown to interact also with the heparin-binding site of FGFR-1. It inhibits the growth of SW13 adrenocortical cells transfected with FGF-4 and tumorigenicity of MCF-7 breast carcinoma cells transfected with FGF-1 or FGF-4.
Dược Động Học :
▧ Absorption :
Slow
▧ Half Life :
4.8 hours
Chỉ Định : For the relief of bladder pain or discomfort associated with interstitial cystitis.
Tương Tác Thuốc :
  • Eptifibatide Pentosan can potentiate adverse effects of antiplatelet agents and thus increase bleeding risk. Combination must be used with caution.
Liều Lượng & Cách Dùng : Capsule - Oral
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : Elmiron 100 mg capsule
    Giá bán buôn : USD >3.32
    Đơn vị tính : capsule
Nhà Sản Xuất
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00686
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=37720
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46509187
ChemSpider
http://www.chemspider.com/Chemical-Structure.34595.html
PharmGKB
http://www.pharmgkb.org/drug/PA164774806
RxList
http://www.rxlist.com/cgi/generic2/pento.htm
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