Tìm theo
Pentolinium
Các tên gọi khác (3) :
  • Pentolineum
  • Pentolonium
  • Pentolonum
antihypertensive agents, nicotinic antagonists, ganglionic blockers
Thuốc Gốc
Small Molecule
CAS: 144-44-5
CTHH: C15H32N2
PTK: 240.428
A nicotinic antagonist that has been used as a ganglionic blocking agent in hypertension. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C15H32N2
Phân tử khối
240.428
Monoisotopic mass
240.256549034
InChI
InChI=1S/C15H32N2/c1-16(12-6-7-13-16)10-4-3-5-11-17(2)14-8-9-15-17/h3-15H2,1-2H3/q+2
InChI Key
InChIKey=XSBSKEQEUFOSDD-UHFFFAOYSA-N
IUPAC Name
1-methyl-1-[5-(1-methylpyrrolidin-1-ium-1-yl)pentyl]pyrrolidin-1-ium
Traditional IUPAC Name
pentolinium
SMILES
C[N+]1(CCCCC[N+]2(C)CCCC2)CCCC1
Độ tan chảy
213 °C (tartrate salt)
Độ hòa tan
1.16e-05 g/l
logP
-6.3
logS
-7.4
Refractivity
99.03 m3·mol-1
Polarizability
31.36 Å3
Polar Surface Area (PSA)
0
Rotatable Bond Count
6
H Bond Acceptor Count
0
H Bond Donor Count
0
Physiological Charge
2
Number of Rings
2
Bioavailability
1
Rule of Five
true
Dược Lực Học : Pentolinium acts as a ganglionic blocking agent. Pentolinium inhibits release of adrenaline and noradrenaline from adrenergic nerves. It is used as an antihypertensive, and can be administered orally, intramuscularly, and subcutaneously.
Cơ Chế Tác Dụng : A nicotinic antagonist that has been used as a ganglionic blocking agent in hypertension. [PubChem] Pentolinium binds to the nicotinic (ganglion) acetylcholine receptor. This receptor/channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. Blockage of the receptor leads to smooth muscle relaxation and vasodilaton.
Độc Tính : Oral, mouse: LD50 = 512 mg/kg; Oral, rat: LD50 = 890 mg/kg.
Chỉ Định : Used to produce controlled hypotension during surgical procedures and in hypertensive crises.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Ansolysen
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01090
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5850
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507977
ChemSpider
http://www.chemspider.com/Chemical-Structure.5641.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50084945
PharmGKB
http://www.pharmgkb.org/drug/PA164777033
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