Tìm theo
Pentagastrin
Các tên gọi khác (1) :
  • Peptavlon
diagnostic agents
Thuốc Gốc
Small Molecule
CAS: 5534-95-2
ATC: V04CG04
CTHH: C37H49N7O9S
PTK: 767.891
A synthetic pentapeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C37H49N7O9S
Phân tử khối
767.891
Monoisotopic mass
767.331246891
InChI
InChI=1S/C37H49N7O9S/c1-22(2)21-53-37(52)39-15-13-31(45)41-29(18-24-20-40-26-12-8-7-11-25(24)26)35(50)42-27(14-16-54-3)34(49)44-30(19-32(46)47)36(51)43-28(33(38)48)17-23-9-5-4-6-10-23/h4-12,20,22,27-30,40H,13-19,21H2,1-3H3,(H2,38,48)(H,39,52)(H,41,45)(H,42,50)(H,43,51)(H,44,49)(H,46,47)/t27-,28-,29-,30-/m0/s1
InChI Key
InChIKey=ALXRNCVIQSDJAO-KRCBVYEFSA-N
IUPAC Name
(3S)-3-{[(1S)-1-carbamoyl-2-phenylethyl]carbamoyl}-3-[(2S)-2-[(2S)-3-(1H-indol-3-yl)-2-(3-{[(2-methylpropoxy)carbonyl]amino}propanamido)propanamido]-4-(methylsulfanyl)butanamido]propanoic acid
Traditional IUPAC Name
pentagastrin
SMILES
CSCC[C@H](NC(=O)[C@H](CC1=CNC2=CC=CC=C12)NC(=O)CCNC(=O)OCC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O
Độ tan chảy
229 dec °C
Độ hòa tan
3.09e-03 g/l
logP
1.6
logS
-5.4
pKa (strongest acidic)
4
PSA
250.91 Å2
Refractivity
199.97 m3·mol-1
Polarizability
80.96 Å3
Rotatable Bond Count
23
H Bond Acceptor Count
8
H Bond Donor Count
8
Physiological Charge
-1
Number of Rings
3
Bioavailability
0
MDDR-Like Rule
true
Dược Lực Học : Pentagastrin is indicated as a diagnostic aid for evaluation of gastric acid secretory function. It is effective in testing for anacidity (achlorhydria) in patients with suspected pernicious anemia, atrophic gastritis, or gastric carcinoma. It is also effective in determining the reduction in acid output after operations for peptic ulcer, such as vagotomy or gastric resection.
Cơ Chế Tác Dụng : A synthetic pentapeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid. [PubChem] The exact mechanism by which pentagastrin stimulates gastric acid, pepsin, and intrinsic factor secretion is unknown; however, since pentagastrin is an analogue of natural gastrin, it is believed that it excites the oxyntic cells of the stomach to secrete to their maximum capacity. Pentagastrin stimulates pancreatic secretion, especially when administered in large intramuscular doses. Pentagastrin also increases gastrointestinal motility by a direct effect on the intestinal smooth muscle. However, it delays gastric emptying time probably by stimulation of terminal antral contractions, which enhance retropulsion.
Dược Động Học :
▧ Absorption :
Rapidly absorbed after parenteral administration.
▧ Metabolism :
Primarily hepatic
▧ Half Life :
10 minutes or less
Chỉ Định : Used as a diagnostic aid for evaluation of gastric acid secretory function
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Peptavlon
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00183
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=444007
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507747
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01631
ChemSpider
http://www.chemspider.com/Chemical-Structure.392037.html
PharmGKB
http://www.pharmgkb.org/drug/PA450849
Wikipedia
http://en.wikipedia.org/wiki/Pentagastrin
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