Tìm theo
Pegfilgrastim
Các tên gọi khác (5 ) :
  • G-CSF
  • Granulocyte colony-stimulating factor precursor
  • Lenograstim
  • N-(3-Hydroxypropyl)Methionylcolony-stimulating Factor (human), 1-Ether with .Alpha.-Methyl-.Omega.-Hydroxypoly(Oxyethylene)
  • Pluripoietin
Thuốc giảm miễn dịch
Thuốc Gốc
Biotech
CAS: 208265-92-3
ATC: L03AA10
ĐG : Amgen Inc. , http://www.amgen.com
CTHH: C845H1343N223O243S9
PTK: 18802.8000
PEGylated (at N terminus) form of human G-CSF (Granulocyte colony stimulating factor), 175 residues, produced from E. coli via bacterial fermentation.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C845H1343N223O243S9
Phân tử khối
18802.8000
Độ tan chảy
60 °C
Độ kỵ nước
0.209
Điểm đẳng điện tích
5.65
Dược Lực Học : Used in the treatment of chemotherapy-induced neutropenia by enhancing the production of neutrophils. Pegfilgrastim acts on hematopoietic cells by binding to specific cell surface receptors thereby stimulating proliferation, differentiation, commitment, and end cell functional activation. Pegfilgrastim has reduced renal clearance and prolonged persistence in vivo as compared to Filgrastim.
Cơ Chế Tác Dụng : PEGylated (at N terminus) form of human G-CSF (Granulocyte colony stimulating factor), 175 residues, produced from E. coli via bacterial fermentation. Pegfilgrastim binds to the G-CSF receptor. As a G-CSF analog, it controls proliferation of committed progenitor cells and influences their maturation into mature neutrophils. Pegfilgrastim also stimulates the release of neutrophils from bone marrow storage pools and reduces their maturation time. Pegfilgrastim acts to increase the phagocytic activity of mature neutrophils. In patients receiving cytotoxic chemotherapy, pegfilgrastim can accelerate neutrophil recovery, leading to a reduction in duration of the neutropenic phase
Dược Động Học :

▧ Route of Elimination :
Filgrastim is primarily eliminated by the kidney and neutrophils/neutrophil precursors; the latter presumably involves binding of the growth factor to the G-CSF receptor on the cell surface, internalization of the growth factor-receptor complexes via endocytosis, and subsequent degradation inside the cells. Pegylation of filgrastim renders renal clearance insignificant, which was demonstrated in bilaterally nephrectomized rats and confirmed in subjects with renal impairment. As a result, the neutrophil-mediated clearance is the predominant elimination pathway for pegfilgrastim. During chemotherapy-induced neutropenia, the clearance of pegfilgrastim is significantly reduced and the concentration of pegfilgrastim is sustained until onset of neutrophil recovery.
▧ Half Life :
15-80 hrs
Chỉ Định : Increases leukocyte production, for treatment in non-myeloid cancer, neutropenia and bone marrow transplant
Liều Lượng & Cách Dùng : Solution - Subcutaneous
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Amgen Inc.
    Sản phẩm biệt dược : Neulasta
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00019
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D06889
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/55513-190-01
GenBank
http://www.ncbi.nlm.nih.gov/nuccore/X03438
PharmGKB
http://www.pharmgkb.org/drug/PA164781387
Wikipedia
http://en.wikipedia.org/wiki/Pegfilgrastim
RxList
http://www.rxlist.com/cgi/generic3/neulasta.htm
Drugs.com
http://www.drugs.com/cdi/pegfilgrastim.html
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