Tìm theo
Paromomycin
Các tên gọi khác (19 ) :
  • (1R,2R,3S,4R,6S)-4,6-Diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside
  • Aminosidin
  • Aminosidine
  • Catenulin
  • Crestomycin
  • Estomycin
  • Hydroxymycin
  • Monomycin a
  • Neomycin e
  • Paromomicina
  • PAROMOMYCIN
  • Paromomycin i
  • Paromomycine
  • Paromomycinum
  • Paucimycin
  • Paucimycinum
  • R 400
  • R-400
  • Zygomycin a1
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 7542-37-2
ATC: A07AA06
ĐG : Caraco Pharmaceutical Labs , http://www.caraco.com
CTHH: C23H45N5O14
PTK: 615.6285
An oligosaccharide antibiotic produced by various streptomyces. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C23H45N5O14
Phân tử khối
615.6285
Monoisotopic mass
615.296301173
InChI
InChI=1S/C23H45N5O14/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22/h5-23,29-36H,1-4,24-28H2/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1
InChI Key
InChIKey=UOZODPSAJZTQNH-LSWIJEOBSA-N
IUPAC Name
(2R,3S,4R,5R,6S)-5-amino-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-2-{[(2S,3R,4S,5R)-4-{[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy}-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy}-3-hydroxycyclohexyl]oxy}-2-(hydroxymethyl)oxane-3,4-diol
Traditional IUPAC Name
(2R,3S,4R,5R,6S)-5-amino-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-2-{[(2S,3R,4S,5R)-4-{[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy}-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy}-3-hydroxycyclohexyl]oxy}-2-(hydroxymethyl)oxane-3,4-diol
SMILES
NC[C@@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)[C@H](N)[C@@H](O)[C@@H]1O
Độ hòa tan
7.97e+01 g/l
logP
-8.3
logS
-0.89
pKa (strongest acidic)
12.23
pKa (Strongest Basic)
9.94
PSA
347.32 Å2
Refractivity
134.24 m3·mol-1
Polarizability
60.4 Å3
Rotatable Bond Count
9
H Bond Acceptor Count
19
H Bond Donor Count
13
Physiological Charge
5
Number of Rings
4
Bioavailability
0
MDDR-Like Rule
true
Dược Lực Học : Paromomycin is a broad spectrum aminoglycoside antibiotic produced by Streptomyces rimosus var. paromomycinus. The in vitro and in vivo antibacterial action of paromomycin closely parallels that of neomycin.
Cơ Chế Tác Dụng : An oligosaccharide antibiotic produced by various streptomyces. [PubChem] Paromomycin inhibits protein synthesis by binding to 16S ribosomal RNA. Bacterial proteins are synthesized by ribosomal RNA complexes which are composed of 2 subunits, a large subunit (50s) and small (30s) subunit, which forms a 70s ribosomal subunit. tRNA binds to the top of this ribosomal structure. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced. Continuous production of defective proteins eventually leads to bacterial death.
Dược Động Học :
▧ Absorption :
Poorly absorbed after oral administration, with almost 100% of the drug recoverable in the stool.
Chỉ Định : For the treatment of acute and chronic intestinal amebiasis (it is not effective in extraintestinal amebiasis). Also for the management of hepatic coma as adjunctive therapy.
Liều Lượng & Cách Dùng : Capsule - Oral
Capsule - Oral
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01421
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=165580
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505391
ChemSpider
http://www.chemspider.com/Chemical-Structure.145115.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/61570-529-10
PharmGKB
http://www.pharmgkb.org/drug/PA164784023
Wikipedia
http://en.wikipedia.org/wiki/Paromomycin_sulfate
RxList
http://www.rxlist.com/cgi/generic/humatin.htm
Drugs.com
http://www.drugs.com/cdi/paromomycin.html
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