Tìm theo
Pancrelipase
Các tên gọi khác (3) :
  • 1,4-alpha-D- glucan glucanohydrolase
  • PA
  • Pancreatic alpha-amylase precursor
gastrointestinal agents, enzyme replacement agents
Thuốc Gốc
Biotech
CAS: 53608-75-6
ATC: A09AA02
ĐG : Axcan Pharma Inc. , http://www.axcan.com
CTHH: C5850H8902N1606O1739S49
PTK: 131125.6000
Pancrelipase is an enzyme mixture isolated from porcine or bovine pancreas, sometimes called pancreatin. It contains 3 enzymes: amylase, lipase, and a protease (chymotrypsin). Pancrelipase is marketed under several brand names such as Ultresa™ and Viokace™.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C5850H8902N1606O1739S49
Phân tử khối
131125.6000
Độ tan chảy
48-50 °C
Điểm đẳng điện tích
6.44
Dược Lực Học : Used in the treatment of cystic fibrosis or pancreatic dysfunction, pancrelipase helps improve fat digestion in the small intestine. Specifically, the lipase, protease and amylase components break down fat, protein, and starches, respectively, in the small intestine. Lipase hydrolyzes fats into glycerol and fatty acids. Protease converts proteins into proteoses and derived substances, while amylase converts starches into dextrins and sugars. Pancreatic enzymes are used to correct maldigestion, malabsorption and pain associated with pancreatic insufficiency. The major maldigestion/malabsorption problems arise from incomplete fat digestion. Exogenous pancrelipase reduces the amount of nitrogen and fat excreted in the stool.
Cơ Chế Tác Dụng : Pancrelipase is an enzyme mixture isolated from porcine or bovine pancreas, sometimes called pancreatin. It contains 3 enzymes: amylase, lipase, and a protease (chymotrypsin). Pancrelipase is marketed under several brand names such as Ultresa™ and Viokace™. The lipase, protease and amylase components of pancrelipase break down fat, protein, and starches, respectively, in the small intestine. Lipase hydrolyzes fats into glycerol and fatty acids. Protease converts proteins into proteoses and derived substances, while amylase converts starches into dextrins and sugars.
Dược Động Học :
▧ Absorption :
Pancrelipase is not significantly absorbed from the gastrointestinal tract.
▧ Volume of Distribution :
Pancrelipase acts locally, so there is no volume of distribution.
▧ Protein binding :
Pancrelipase acts locally, so there is minimal plasma protein binding.
▧ Metabolism :
Pancrelipase acts locally, so there is minimal metabolism.
▧ Route of Elimination :
Pancrelipase is eliminated in the feces.
▧ Half Life :
Pancrelipase is not significantly absorbed from the gastrointestinal tract and acts locally, so there is no terminal elimination half life.
▧ Clearance :
Pancrelipase is not significantly absorbed, so there is minimal clearance from the body.
Độc Tính : Overdose symptoms may include diarrhea or stomach upset. The most common adverse reactions seen are ear, neck, and abdominal pain; headache, nasal congestion, and beta-hemolytic streptococcal infection.
Chỉ Định : For treatment of exocrine pancreatic insufficiency in cystic fibrosis (Ultresa™), chronic pancreatitis (Viokace™ in combination with a proton pump inhibitor), and pancreatectomy (Viokace™ in combination with a proton pump inhibitor).
Tương Tác Thuốc :
  • Iron If pancrelipase and iron salts are used in combination then monitor therapy. Pancrelipase may decrease the absorption of iron salts except for ferumoxytol, iron dextran complex, and iron sucrose.
Liều Lượng & Cách Dùng : Capsule, coated - Oral
Capsule, delayed release - Oral - ULTRESA : 27,600USP UNITS; 13,800USP UNITS; 27,600USP UNITS (AMYLASE;LIPASE;PROTEASE)
Capsule, delayed release - Oral - ULTRESA : 41,400USP UNITS; 20,700USP UNITS; 41,400USP UNITS (AMYLASE;LIPASE;PROTEASE)
Capsule, delayed release - Oral - ULTRESA: 46,000USP UNITS; 23,000USP UNITS; 46,000USP UNITS (AMYLASE;LIPASE;PROTEASE)
Tablet - Oral - VIOKACE : 39,150USP UNITS; 10,440USP UNITS; 39,150USP UNITS (AMYLASE;LIPASE;PROTEASE)
Tablet - Oral - VIOKACE: 78,300USP UNITS; 20,880USP UNITS; 78,300USP UNITS PANCRELIPASE (AMYLASE;LIPASE;PROTEASE)
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Organon
    Sản phẩm biệt dược : Cotazym
  • Công ty :
    Sản phẩm biệt dược : Creon
  • Công ty : Koichi
    Sản phẩm biệt dược : Ku-Zyme
  • Công ty : Ortho-McNeil
    Sản phẩm biệt dược : Pancrease
  • Công ty :
    Sản phẩm biệt dược : PANCREAZE
  • Công ty :
    Sản phẩm biệt dược : PERTZYE
  • Công ty :
    Sản phẩm biệt dược : Polocaine-MPF
  • Sản phẩm biệt dược : Ultrase
  • Công ty :
    Sản phẩm biệt dược : ULTRESA
  • Sản phẩm biệt dược : Ultresa (delayed-release enteric coated capsules)
  • Công ty :
    Sản phẩm biệt dược : Viokace
  • Sản phẩm biệt dược : Viokace (tablets)
  • Công ty :
    Sản phẩm biệt dược : ZENPEP
  • Công ty : Organon
    Sản phẩm biệt dược : Zymase
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00085
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D05349
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/54868-6067-0
GenBank
http://www.ncbi.nlm.nih.gov/nuccore/M18785
PharmGKB
http://www.pharmgkb.org/drug/PA448428
Wikipedia
http://en.wikipedia.org/wiki/Pancrelipase
RxList
http://www.rxlist.com/cgi/generic2/pancrel.htm
Drugs.com
http://www.drugs.com/cdi/amylase-lipase-protease.html
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