Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
Dược Lực Học :
Used in the prevention or treatment of oral mucoscitis (mouth ulcers arising from chemotherapy), Kepivance binds to the human keratinocyte growth factor (KGF) receptor on buccal cell surfaces. Kepivance acts as both a cell growth and survival factor by stimulating epithelial cell proliferation, differentiation, and migration around the tongue and mouth. The KGF receptor is found on many tissues particularly around the tongue, esophagus, salivary gland and other gastro-intestinal tract organs.
Cơ Chế Tác Dụng :
Palifermin is a recombinant human keratinocyte growth factor (KGF). It is 140 residues long, and is produced using E. coli.
Kepivance binds to the human keratinocyte growth factor (KGF) receptor found on buccal cell surfaces. The binding activates a Ras-MapK (Map kinase) signaling pathway which leads to the transcriptional activation of many proteins important for cell growth and survival.
Dược Động Học :
▧ Half Life :
Elimination half-life: 4.5 hours (range: 3.3-5.7 hours)
Chỉ Định :
For treatment of oral mucositis associated with chemotherapy and radiation therapy.
Tương Tác Thuốc :
Increases toxicity of bendamustine. Should not be administered within a 24 hour time period of antineoplastic agent administration.
Increases the toxicity of pralatrexate. Avoid concomitant therapy or do not use palifermin within 24 hours after administration of pralatrexate.
Liều Lượng & Cách Dùng :
Powder, for solution - Intravenous
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