Tìm theo
Pagoclone
Thuốc an thần
Thuốc Gốc
Small Molecule
CAS: 133737-32-3
CTHH: C23H22ClN3O2
PTK: 407.893
Pagoclone is an anxiolytic drug from the cyclopyrrolone family, which is related to other more well known drugs such as the sleeping medication zopiclone. It is one of a relatively recently developed class of medicines known as the nonbenzodiazepines, which have similar effects to the older benzodiazepine group, but with quite different chemical structures.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C23H22ClN3O2
Phân tử khối
407.893
Monoisotopic mass
407.14005467
InChI
InChI=1S/C23H22ClN3O2/c1-14(2)7-10-16(28)13-19-17-5-3-4-6-18(17)23(29)27(19)21-12-9-15-8-11-20(24)25-22(15)26-21/h3-6,8-9,11-12,14,19H,7,10,13H2,1-2H3
InChI Key
InChIKey=HIUPRQPBWVEQJJ-UHFFFAOYSA-N
IUPAC Name
2-(7-chloro-1,8-naphthyridin-2-yl)-3-(5-methyl-2-oxohexyl)-2,3-dihydro-1H-isoindol-1-one
Traditional IUPAC Name
pagoclone
SMILES
CC(C)CCC(=O)CC1N(C(=O)C2=CC=CC=C12)C1=NC2=C(C=CC(Cl)=N2)C=C1
Độ hòa tan
6.55e-03 g/l
logP
5.35
logS
-4.8
pKa (strongest acidic)
13.39
pKa (Strongest Basic)
-2.6
PSA
63.16 Å2
Refractivity
115.16 m3·mol-1
Polarizability
44.23 Å3
Rotatable Bond Count
6
H Bond Acceptor Count
4
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
4
Bioavailability
1
Ghose Filter
true
MDDR-Like Rule
true
Dược Lực Học : Pagoclone was originally developed as an anti-anxiety drug, but never commercialised. It is a partial agonist acting at GABAA receptors in the brain. In contrast to zopiclone, pagoclone produces anxiolytic effects with little or no sedative or amnestic actions at low doses.
Cơ Chế Tác Dụng : Pagoclone is an anxiolytic drug from the cyclopyrrolone family, which is related to other more well known drugs such as the sleeping medication zopiclone. It is one of a relatively recently developed class of medicines known as the nonbenzodiazepines, which have similar effects to the older benzodiazepine group, but with quite different chemical structures. Pagoclone is a subtype-selective drug which binds primarily to the alpha2/alpha3 subtypes of the GABAA receptor which are responsible for the anti-anxiety effects of these kind of drugs, but has relatively little efficacy at the alpha1 subtype which produces the sedative and memory loss effects.
Chỉ Định : For the potential treatment of panic and anxiety disorders.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB04903
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=131664
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=10242921
ChemSpider
http://www.chemspider.com/Chemical-Structure.116335.html
Wikipedia
http://en.wikipedia.org/wiki/Pagoclone
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