Tìm theo
Oxytetracycline
Các tên gọi khác (12 ) :
  • 5-Hydroxytetracycline
  • Embryostat
  • Hydroxytetracyclinum
  • Mepatar
  • Oxitetraciclina
  • Oxyterracin
  • Oxyterracine
  • Oxytetracyclin
  • Oxytétracycline
  • Oxytetracycline (anhydrous)
  • Oxytetracycline amphoteric
  • Oxytetracyclinum
tetracyclines
Thuốc Gốc
Small Molecule
CAS: 79-57-2
ATC: D06AA03, G01AA07, J01AA06, S01AA04
ĐG : Chifeng Pharmaceutical Co. Ltd. , http://www.chifengpharma.com
CTHH: C22H24N2O9
PTK: 460.434
A tetracycline analog isolated from the actinomycete streptomyces rimosus and used in a wide variety of clinical conditions. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C22H24N2O9
Phân tử khối
460.434
Monoisotopic mass
460.148180376
InChI
InChI=1S/C22H24N2O9/c1-21(32)7-5-4-6-8(25)9(7)15(26)10-12(21)17(28)13-14(24(2)3)16(27)11(20(23)31)19(30)22(13,33)18(10)29/h4-6,12-14,17,25,27-29,32-33H,1-3H3,(H2,23,31)/t12-,13-,14+,17+,21-,22+/m1/s1
InChI Key
InChIKey=IWVCMVBTMGNXQD-PXOLEDIWSA-N
IUPAC Name
(4S,4aR,5S,5aR,6S,12aS)-4-(dimethylamino)-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
Traditional IUPAC Name
oxytetracycline
SMILES
[H][C@@]12[C@@H](O)[C@@]3([H])C(C(=O)C4=C(O)C=CC=C4[C@@]3(C)O)=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@H]2N(C)C
Độ tan chảy
184.5 °C
Độ hòa tan
313 mg/L (at 25 °C)
logP
-0.90
logS
-3.14
pKa (strongest acidic)
0.24
pKa (Strongest Basic)
7.75
PSA
201.85 Å2
Refractivity
115.4 m3·mol-1
Polarizability
43.4 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
10
H Bond Donor Count
7
Physiological Charge
-1
Number of Rings
4
Bioavailability
0
pKa
3.27 (at 25 °C)
Dược Lực Học : Oxytetracycline is known as a broad-spectrum antibiotic due to its activity against such a wide range of infections. It was the second of the tetracyclines to be discovered. Oxytetracycline, like other tetracyclines, is used to treat many infections common and rare. Its better absorption profile makes it preferable to tetracycline for moderately severe acne, but alternatives sould be sought if no improvement occurs by 3 months.
Cơ Chế Tác Dụng : A tetracycline analog isolated from the actinomycete streptomyces rimosus and used in a wide variety of clinical conditions. [PubChem] Oxytetracycline inhibits cell growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Oxytetracycline is lipophilic and can easily pass through the cell membrane or passively diffuses through porin channels in the bacterial membrane.
Dược Động Học :
▧ Absorption :
Readily absorbed following oral administration.
Độc Tính : Adverse effects may include stomach or bowel upsets and rarely allergic reactions. Very rarely severe headache and vision problems may be signs of dangerous intracranial hypertenion.
Chỉ Định : Oxytetracycline is indicated for treatment of infections caused by a variety of Gram positive and Gram negative microorganisms including Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae (respiratory infections), and Diplococcus pneumoniae.
Tương Tác Thuốc :
  • Acitretin Increased risk of intracranial hypertension
  • Amoxicillin Possible antagonism of action
  • Ampicillin Possible antagonism of action
  • Benzylpenicillin Possible antagonism of action
  • Calcium Formation of non-absorbable complexes
  • Carbenicillin Possible antagonism of action
  • Clavulanate Possible antagonism of action
  • Cloxacillin Possible antagonism of action
  • Dicloxacillin Possible antagonism of action
  • Ethinyl Estradiol This anti-infectious agent could decrease the effect of the oral contraceptive
  • Etretinate Increased risk of intracranial hypertension
  • Flucloxacillin Possible antagonism of action
  • Iron Dextran Formation of non-absorbable complexes
  • Isotretinoin Increased risk of intracranial hypertension
  • Magnesium Formation of non-absorbable complexes
  • Penicillin V Possible antagonism of action
  • Piperacillin Possible antagonism of action
  • Pivampicillin Possible antagonism of action
  • Pivmecillinam Possible antagonism of action
  • Ticarcillin Oxytetracycline may reduce the effect of Ticarcillin by inhibiting bacterial growth. Ticarcillin exerts its effects on actively growing bacteria. To achieve synergism, Ticarcillin should be administered at least 2 hours prior to using Oxytetracycline.
  • Tretinoin Oxytetracycline may increase the adverse effects of oral Tretinoin. Increase risk of pseudotumour cerebri. Concurrent therapy should be avoided.
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
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  • Sản phẩm biệt dược : Oxypan
  • Công ty : Chema
    Sản phẩm biệt dược : Oxyterracyna
  • Công ty : Pfizer
    Sản phẩm biệt dược : Terrados
  • Công ty : Pfizer
    Sản phẩm biệt dược : Terramycin
  • Công ty : Wagner Pharmafax
    Sản phẩm biệt dược : Tetran
  • Công ty : Medifarma
    Sản phẩm biệt dược : Tetrasona
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00595
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5280972
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507025
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C06624
ChemSpider
http://www.chemspider.com/Chemical-Structure.4444458.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0069-0730-66
PharmGKB
http://www.pharmgkb.org/drug/PA450757
Wikipedia
http://en.wikipedia.org/wiki/Oxytetracycline
RxList
http://www.rxlist.com/cgi/generic2/oxytetracycline.htm
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