Tìm theo
Oxypurinol
Các tên gọi khác (11 ) :
  • 1H-Pyrazolo[3,4-d]pyrimidine-4,6-diol
  • 1H-Pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione
  • 6-hydroxy allopurinol
  • Alloxanthin
  • Alloxanthine
  • DHPP
  • metabolite of allopurinol
  • Oxipurinol
  • Oxipurinolum
  • Oxoallopurinol
  • Oxyprim
enzyme inhibitors
Thuốc Gốc
Small Molecule
CAS: 2465-59-0
CTHH: C5H4N4O2
PTK: 152.1109
Oxypurinol, an inhibitor of xanthine oxidase, is a metabolite of allopurinol.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C5H4N4O2
Phân tử khối
152.1109
Monoisotopic mass
152.033425392
InChI
InChI=1S/C5H4N4O2/c10-4-2-1-6-9-3(2)7-5(11)8-4/h1H,(H3,6,7,8,9,10,11)
InChI Key
InChIKey=HXNFUBHNUDHIGC-UHFFFAOYSA-N
IUPAC Name
1H,2H,4H,5H,6H-pyrazolo[3,4-d]pyrimidine-4,6-dione
Traditional IUPAC Name
oxypurinol
SMILES
O=C1NC(=O)C2=CNNC2=N1
Độ hòa tan
2.32e+00 g/l
logP
-1.7
logS
-1.8
pKa (strongest acidic)
7.19
pKa (Strongest Basic)
-3.7
PSA
82.59 Å2
Refractivity
55.35 m3·mol-1
Polarizability
12.6 Å3
Rotatable Bond Count
0
H Bond Acceptor Count
5
H Bond Donor Count
3
Physiological Charge
0
Number of Rings
2
Bioavailability
1
Rule of Five
true
Cơ Chế Tác Dụng : Oxypurinol, an inhibitor of xanthine oxidase, is a metabolite of allopurinol. Oxypurinol inhibits the enzyme xanthine oxidase, blocking the conversion of the oxypurines hypoxanthine and xanthine to uric acid. Elevated concentrations of oxypurine and oxypurine inhibition of xanthine oxidase through negative feedback results in a decrease in the concentrations of uric acid in the blood and urine. Oxypurinol also facilitates the incorporation of hypoxanthine and xanthine into DNA and RNA, resulting in further reductions of serum uric acid concentrations.
Dược Động Học :

▧ Half Life :
23.3 +/- 6.0 hours
Chỉ Định : Intended for the treatment of congestive heart failure and hyperuricemia.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Oxypurinol
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB05262
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=4644
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=7849424
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07599
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D02365
ChemSpider
http://www.chemspider.com/Chemical-Structure.4483.html
... loading
... loading