Tìm theo
Oxyphenonium
Các tên gọi khác (1) :
  • Oxyphenonium
Thuốc Gốc
Small Molecule
CAS: 50-10-2
ATC: A03AB03
CTHH: C21H34NO3
PTK: 348.4996
A quaternary ammonium anticholinergic agent with peripheral side effects similar to those of atropine. It is used as an adjunct in the treatment of gastric and duodenal ulcer, and to relieve visceral spasms. The drug has also been used in the form of eye drops for mydriatic effect. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C21H34NO3
Phân tử khối
348.4996
Monoisotopic mass
348.253868959
InChI
InChI=1S/C21H34NO3/c1-4-22(3,5-2)16-17-25-20(23)21(24,18-12-8-6-9-13-18)19-14-10-7-11-15-19/h6,8-9,12-13,19,24H,4-5,7,10-11,14-17H2,1-3H3/q+1
InChI Key
InChIKey=GFRUPHOKLBPHTQ-UHFFFAOYSA-N
IUPAC Name
{2-[(2-cyclohexyl-2-hydroxy-2-phenylacetyl)oxy]ethyl}diethylmethylazanium
Traditional IUPAC Name
{2-[(2-cyclohexyl-2-hydroxy-2-phenylacetyl)oxy]ethyl}diethylmethylazanium
SMILES
CC[N+](C)(CC)CCOC(=O)C(O)(C1CCCCC1)C1=CC=CC=C1
Độ tan chảy
191.5 °C
Độ hòa tan
1.36e-04 g/l
logP
0.17
logS
-6.5
pKa (strongest acidic)
11.53
pKa (Strongest Basic)
-4.3
PSA
46.53 Å2
Refractivity
112.61 m3·mol-1
Polarizability
40.65 Å3
Rotatable Bond Count
9
H Bond Acceptor Count
2
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Oxyphenonium is an anticholinergic drug, a medication that reduces the effect of acetylcholine, a chemical released from nerves that stimulates muscles, by blocking the receptors for acetylcholine on smooth muscle (a type of muscle). It also has a direct relaxing effect on smooth muscle. Oxyphenonium is used to treat or prevent spasm in the muscles of the gastrointestinal tract in the irritable bowel syndrome. In addition, Oxyphenonium inhibits gastrointestinal propulsive motility and decreases gastric acid secretion and controls excessive pharyngeal, tracheal and bronchial secretions.
Cơ Chế Tác Dụng : A quaternary ammonium anticholinergic agent with peripheral side effects similar to those of atropine. It is used as an adjunct in the treatment of gastric and duodenal ulcer, and to relieve visceral spasms. The drug has also been used in the form of eye drops for mydriatic effect. [PubChem] Action is achieved via a dual mechanism: (1) a specific anticholinergic effect (antimuscarinic) at the acetylcholine-receptor sites and (2) a direct effect upon smooth muscle (musculotropic).
Dược Động Học :

▧ Protein binding :
93% bound to albumin
Chỉ Định : For the treatment of visceral spasms
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : A-Spasm
  • Công ty :
    Sản phẩm biệt dược : Antispasmin
  • Công ty :
    Sản phẩm biệt dược : Antrenex
  • Công ty :
    Sản phẩm biệt dược : Antrenyl
  • Công ty :
    Sản phẩm biệt dược : Atrenex
  • Công ty :
    Sản phẩm biệt dược : Spasmophen
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00219
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5749
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508840
ChemSpider
http://www.chemspider.com/Chemical-Structure.5547.html
PharmGKB
http://www.pharmgkb.org/drug/PA164752252
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