Tìm theo
Oxyphencyclimine
Các tên gọi khác (3) :
  • Oxifencicliminum
  • Oxyphencyclimine
  • Oxyphencycliminum
cholinergic antagonists, antispasmodics
Thuốc Gốc
Small Molecule
CAS: 125-53-1
ATC: A03AA01
ĐG : Professional Co.
CTHH: C20H28N2O3
PTK: 344.4479
Oxyphencyclimine is an anticholinergic drug (trade name Daricon) used in treating peptic ulcers.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C20H28N2O3
Phân tử khối
344.4479
Monoisotopic mass
344.209992772
InChI
InChI=1S/C20H28N2O3/c1-22-14-8-13-21-18(22)15-25-19(23)20(24,16-9-4-2-5-10-16)17-11-6-3-7-12-17/h2,4-5,9-10,17,24H,3,6-8,11-15H2,1H3
InChI Key
InChIKey=DUDKAZCAISNGQN-UHFFFAOYSA-N
IUPAC Name
(1-methyl-1,4,5,6-tetrahydropyrimidin-2-yl)methyl 2-cyclohexyl-2-hydroxy-2-phenylacetate
Traditional IUPAC Name
oxyphencyclimine
SMILES
CN1CCCN=C1COC(=O)C(O)(C1CCCCC1)C1=CC=CC=C1
Độ hòa tan
6.61 mg/L at 25 °C
logP
3.7
logS
-3.8
pKa (strongest acidic)
11.53
pKa (Strongest Basic)
8.37
PSA
62.13 Å2
Refractivity
97.13 m3·mol-1
Polarizability
38.34 Å3
Rotatable Bond Count
6
H Bond Acceptor Count
4
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
MDDR-Like Rule
true
Dược Lực Học : Oxyphencyclimine is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. Oxyphencyclimine is an antimuscarinic, anticholinergic drug.
Cơ Chế Tác Dụng : Oxyphencyclimine is an anticholinergic drug (trade name Daricon) used in treating peptic ulcers. Oxyphencyclimine binds the muscarinic acetylcholine receptor. It may block all three types of muscarinic receptors including M-1 receptors in the CNS and ganglia, M-2 receptors in the heart (vagus) and M-3 receptors at the parasympathetic NEJ system. The muscarinic acetylcholine receptors mediate various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Oxphencyclimine inhibits vagally mediated reflexes by antagonizing the action of acetylcholine. This in turn reduces the secretion of gastric acids in the stomach.
Chỉ Định : For the treatment of peptic ulcer disease and the relief of smooth muscle spasms in gastrointestinal disorders.
Tương Tác Thuốc :
  • Haloperidol The anticholinergic increases the risk of psychosis and tardive dyskinesia
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Proclimine
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00383
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=4642
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507487
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07851
ChemSpider
http://www.chemspider.com/Chemical-Structure.4481.html
PharmGKB
http://www.pharmgkb.org/drug/PA164776910
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