Tìm theo
Oxitriptan
Các tên gọi khác (8 ) :
  • 5-Hydroxy-L-Tryptophan
  • 5-Hydroxytryptophan L-form
  • Cincofarm
  • Hydroxy-5 L-tryptophane
  • L-5-Hydroxytryptophan
  • Levothym
  • Oxitriptan
  • Tript-OH
antidepressive agents second generation
Thuốc Gốc
Small Molecule
CAS: 4350-09-8
ATC: N06AX01
CTHH: C11H12N2O3
PTK: 220.2246
5-Hydroxytryptophan (5-HTP), also known as oxitriptan (INN), is a naturally occurring amino acid and chemical precursor as well as a metabolic intermediate in the biosynthesis of the neurotransmitters serotonin and melatonin from tryptophan. 5-HTP is sold over-the-counter in the United Kingdom, United States and Canada as a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, and is also marketed in many European countries for the indication of major depression under trade names like Cincofarm, Levothym, Levotonine, Oxyfan, Telesol, Tript-OH, and Triptum. Several double-blind placebo-controlled clinical trials have demonstrated the effectiveness of 5-HTP in the treatment of depression, though a lack of high quality studies has been noted. More and larger studies are needed to determine if 5-HTP is truly effective in treating depression.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C11H12N2O3
Phân tử khối
220.2246
Monoisotopic mass
220.08479226
InChI
InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1
InChI Key
InChIKey=LDCYZAJDBXYCGN-VIFPVBQESA-N
IUPAC Name
(2S)-2-amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid
Traditional IUPAC Name
L-5-hydroxytryptophan
SMILES
N[C@@H](CC1=CNC2=C1C=C(O)C=C2)C(O)=O
Độ tan chảy
295-297
Độ hòa tan
3.63e+00 g/l
logP
-1.4
logS
-1.8
pKa (strongest acidic)
2.15
pKa (Strongest Basic)
9.18
PSA
99.34 Å2
Refractivity
58.18 m3·mol-1
Polarizability
22.03 Å3
Rotatable Bond Count
3
H Bond Acceptor Count
4
H Bond Donor Count
4
Physiological Charge
0
Number of Rings
2
Bioavailability
1
Rule of Five
true
Dược Lực Học : The psychoactive action of 5-HTP is derived from its effect on the production of serotonin in central nervous system tissue. More specifically, 5-HTP increases the production of serotonin.
Dược Động Học :

▧ Metabolism :
5-Hydroxytryptophan is decarboxylated to serotonin (5-hydroxytryptamine or 5-HT) by the enzyme aromatic-L-amino-acid decarboxylase with the help of vitamin B6. This reaction occurs both in nervous tissue and in the liver.
Chỉ Định : For use as an antidepressant, appetite suppressant, and sleep aid.
Liều Lượng & Cách Dùng : Capsule - Oral - 100mg
Capsule - Oral - 50mg
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty : Lundbeck
    Sản phẩm biệt dược : Levothym
  • Công ty : Nativelle
    Sản phẩm biệt dược : Quietim
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB02959
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C00643
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D07339
Wikipedia
http://en.wikipedia.org/wiki/5-Hydroxytryptophan
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