Tìm theo
Oxiconazole
Các tên gọi khác (2) :
  • Oxiconazol
  • Oxiconazolum
antifungal agents
Thuốc Gốc
Small Molecule
CAS: 64211-46-7
ATC: D01AC11, G01AF17
ĐG : Dispensing Solutions , http://www.drxdispensing.com
CTHH: C18H13Cl4N3O
PTK: 429.127
Oxiconazole nitrate (U.S.: Oxistat, Canada: Oxizole) is an antifungal medication typically administered in a cream or lotion to treat skin infections such as athlete's foot, jock itch and ringworm. [Wikipedia]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C18H13Cl4N3O
Phân tử khối
429.127
Monoisotopic mass
426.981272881
InChI
InChI=1S/C18H13Cl4N3O/c19-13-2-1-12(16(21)7-13)10-26-24-18(9-25-6-5-23-11-25)15-4-3-14(20)8-17(15)22/h1-8,11H,9-10H2/b24-18-
InChI Key
InChIKey=QRJJEGAJXVEBNE-MOHJPFBDSA-N
IUPAC Name
(E)-[1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethylidene][(2,4-dichlorophenyl)methoxy]amine
Traditional IUPAC Name
oxiconazole
SMILES
ClC1=CC(Cl)=C(CO\N=C(\CN2C=CN=C2)C2=C(Cl)C=C(Cl)C=C2)C=C1
Độ hòa tan
1.91e-03 g/l
logP
5.84
logS
-5.3
pKa (Strongest Basic)
6.74
PSA
39.41 Å2
Refractivity
105.95 m3·mol-1
Polarizability
40.01 Å3
Rotatable Bond Count
6
H Bond Acceptor Count
3
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
3
Bioavailability
1
MDDR-Like Rule
true
Dược Lực Học : Oxiconazole is a broad-spectrum imidazole derivative whose antifungal activity is derived primarily from the inhibition of ergosterol biosynthesis, which is critical for cellular membrane integrity. It has fungicidal or fungistatic activity in vitro against a number of pathogenic fungi including the following dermatophytes, and yeasts: T. rubrum, T. mentagrophytes, T. tonsurans, T. violaceum, E. floccosum, M. canis, M. audouini, M. gypseum, C. albicans, and M. furfur.
Cơ Chế Tác Dụng : Oxiconazole nitrate (U.S.: Oxistat, Canada: Oxizole) is an antifungal medication typically administered in a cream or lotion to treat skin infections such as athlete's foot, jock itch and ringworm. [Wikipedia] Oxiconazole inhibits ergosterol biosynthesis, which is required for cytoplasmic membrane integrity of fungi. It acts to destabilize the fungal cyctochrome P450 51 enzyme (also known as Lanosterol 14-alpha demethylase). This is vital in the cell membrance structure of the fungus. Its inhibition leads to cell lysis. Oxiconazole has also been shown in inhibit DNA synthesis and suppress intracellular concentrations of ATP. Like other imidazole antifungals, Oxiconazole can increase membrane permeability to zinc, augmenting its cytotoxicity.
Dược Động Học :
▧ Absorption :
Systemic absorption of oxiconazole is low.
Độc Tính : Side effects incliude pruritus, burning, irritation, erythema, stinging and allergic contact dermatitis and folliculitis, fissuring, maceration rash and nodules.
Chỉ Định : For treatment of dermal fungal infection.
Liều Lượng & Cách Dùng : Cream - Topical
Lotion - Topical
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Oxistat
  • Công ty :
    Sản phẩm biệt dược : Oxizole
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00239
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5361463
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46504752
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C08075
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00885
ChemSpider
http://www.chemspider.com/Chemical-Structure.4514745.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0173-0423-00
PharmGKB
http://www.pharmgkb.org/drug/PA164754742
Wikipedia
http://en.wikipedia.org/wiki/Oxiconazole
RxList
http://www.rxlist.com/cgi/generic3/oxico.htm
PDRhealth
http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/oxi1314.shtml
Drugs.com
http://www.drugs.com/cdi/oxiconazole-cream.html
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