Tìm theo
Oxibendazole
Các tên gọi khác (10 ) :
  • (5-Propoxy-1H-benzimidazol-2-yl)carbamic acid methyl ester
  • 5-Propoxy-2-benzimidazolecarbamic acid methyl ester
  • Methyl (5-propoxy-1H-benzimidazol-2-yl)carbamate
  • methyl 5-[n-propoxy]benzimidazole-2-carbamate
  • Methyl 5-n-propoxy-2-benzimidazole carbamate
  • Methyl 5-propoxy-2-benzimidazolecarbamate
  • OBZ
  • Oxibendazolo
  • Oxibendazolum
  • Oxybendazole
anthelmintics
Thuốc Gốc
Small Molecule
CAS: 20559-55-1
CTHH: C12H15N3O3
PTK: 249.2658
Oxibendazole is a polymerase inhibitor in phase III trials for the treatment of helminth intestinal infections.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C12H15N3O3
Phân tử khối
249.2658
Monoisotopic mass
249.111341361
InChI
InChI=1S/C12H15N3O3/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)
InChI Key
InChIKey=RAOCRURYZCVHMG-UHFFFAOYSA-N
IUPAC Name
methyl N-(6-propoxy-1H-1,3-benzodiazol-2-yl)carbamate
Traditional IUPAC Name
oxibendazole
SMILES
CCCOC1=CC2=C(C=C1)N=C(NC(=O)OC)N2
Độ tan chảy
230 °C
Độ hòa tan
3.47e-01 g/l
logP
2.52
logS
-2.9
pKa (strongest acidic)
9.64
pKa (Strongest Basic)
4.56
PSA
76.24 Å2
Refractivity
66.66 m3·mol-1
Polarizability
26.98 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
4
H Bond Donor Count
2
Physiological Charge
0
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Cơ Chế Tác Dụng : Oxibendazole is a polymerase inhibitor in phase III trials for the treatment of helminth intestinal infections. Oxibendazole causes degenerative alterations in the tegument and intestinal cells of the worm by binding to the colchicine-sensitive site of tubulin, thus inhibiting its polymerization or assembly into microtubules. The loss of the cytoplasmic microtubules leads to impaired uptake of glucose by the larval and adult stages of the susceptible parasites, and depletes their glycogen stores. Degenerative changes in the endoplasmic reticulum, the mitochondria of the germinal layer, and the subsequent release of lysosomes result in decreased production of adenosine triphosphate (ATP), which is the energy required for the survival of the helminth. Due to diminished energy production, the parasite is immobilized and eventually dies.
Dược Động Học :

▧ Metabolism :
Hepatic
Chỉ Định : Investigated for use/treatment in infectious and parasitic disease (unspecified) and pediatric indications.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Loditac
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB04910
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=4622
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=10486937
ChemSpider
http://www.chemspider.com/Chemical-Structure.4461.html
Wikipedia
http://en.wikipedia.org/wiki/Oxibendazole
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