Tìm theo
Oxamniquine
Các tên gọi khác (2) :
  • Mansil
  • Vansil
Thuốc Gốc
Small Molecule
CAS: 21738-42-1
ATC: P02BA02
CTHH: C14H21N3O3
PTK: 279.3348
An anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Oxamniquine causes worms to shift from the mesenteric veins to the liver where the male worms are retained; the female worms return to the mesentery, but can no longer release eggs. (From Martidale, The Extra Pharmacopoeia, 31st ed, p121)
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C14H21N3O3
Phân tử khối
279.3348
Monoisotopic mass
279.158291553
InChI
InChI=1S/C14H21N3O3/c1-9(2)15-7-12-4-3-10-5-11(8-18)14(17(19)20)6-13(10)16-12/h5-6,9,12,15-16,18H,3-4,7-8H2,1-2H3
InChI Key
InChIKey=XCGYUJZMCCFSRP-UHFFFAOYSA-N
IUPAC Name
(7-nitro-2-{[(propan-2-yl)amino]methyl}-1,2,3,4-tetrahydroquinolin-6-yl)methanol
Traditional IUPAC Name
oxamniquine
SMILES
CC(C)NCC1CCC2=CC(CO)=C(C=C2N1)[N+]([O-])=O
Độ tan chảy
147-149 °C
Độ hòa tan
820 mg/L
logP
2.24
logS
-3.4
pKa (strongest acidic)
14.55
pKa (Strongest Basic)
9.9
PSA
90.11 Å2
Refractivity
79.87 m3·mol-1
Polarizability
30.19 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
5
H Bond Donor Count
3
Physiological Charge
1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Oxamniquine is an anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Oxamniquine causes worms to shift from the mesenteric veins to the liver where the male worms are retained; the female worms return to the mesentery, but can no longer release egg.
Cơ Chế Tác Dụng : An anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Oxamniquine causes worms to shift from the mesenteric veins to the liver where the male worms are retained; the female worms return to the mesentery, but can no longer release eggs. (From Martidale, The Extra Pharmacopoeia, 31st ed, p121) Oxamniquine may associate with an irreversible inhibition of the nucleic acid metabolism of the parasites. A hypothesis has been put forth that the drug is activated by a single step, in which a schistosome sulfotransferase enzyme converts oxamniquine into an ester (probably acetate, phosphate, or sulfate). Subsequently, the ester spontaneously dissociates, the resulting electrophilic reactant is capable of alkylation of schistosome DNA.
Dược Động Học :
▧ Absorption :
Well absorbed orally
▧ Metabolism :
Probably hepatic
▧ Half Life :
1-2.5 hours
Chỉ Định : For treatment of Schistosomiasis caused by Schistosoma mansoni
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Mansil
  • Công ty :
    Sản phẩm biệt dược : Vansil
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01096
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=4612
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508789
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07341
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00460
ChemSpider
http://www.chemspider.com/Chemical-Structure.4451.html
PharmGKB
http://www.pharmgkb.org/drug/PA164748782
Wikipedia
http://en.wikipedia.org/wiki/Oxamniquine
Drugs.com
http://www.drugs.com/mtm/oxamniquine.html
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