Tìm theo
Oregovomab
Các tên gọi khác (4 ) :
  • B43.13
  • MOAB B43.13
  • Monoclonal antibody B43.13
  • Oregovamab
Thuốc điều trị ung thư
Thuốc Gốc
Biotech
Oregovomab is a murine monoclonal antibody that attaches to the tumor-associated antigen CA125.
Dược Lực Học : Oregovomab is well tolerated and induces multiple antigen-specific immune responses, maintained during concomitant chemotherapy. A significant survival benefit has been observed in patients mounting a T-cell response to CA125 and/or autologous tumor. Vaccination with oregovomab may stimulate a host cytotoxic immune response against tumor cells that express CA125.
Cơ Chế Tác Dụng : Oregovomab is a murine monoclonal antibody that attaches to the tumor-associated antigen CA125. Oregovomab targets the circulating tumour-associated antigen CA 125, which is shed from the surface of human ovarian cancer cells; the antibodies induce broad cellular and humoral immune responses against CA 125 via complex formation. Unlike free CA 125, CA 125-oregovomab complexes can prime dendritic cells, leading to downstream activation of T cells.
Chỉ Định : Investigated for use/treatment in ovarian cancer.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : OvaRex
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB04964
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